1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. CB2R PAM

CB2R PAM 

Cat. No.: HY-131004
Handling Instructions

CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.

For research use only. We do not sell to patients.

CB2R PAM Chemical Structure

CB2R PAM Chemical Structure

CAS No. : 2244579-87-9

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Description

CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].

IC50 & Target[1]

cannabinoid type-2 receptors

 

In Vitro

CB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)[1]
Dosage: 1, 5, 10, 20 mg/kg
Administration: P.o.
Result: Significantly increased licking latency in the animals starting from 5 mg/kg.
Molecular Weight

435.33

Formula

C₂₁H₂₄BrFN₂O₂

CAS No.

2244579-87-9

SMILES

FC1=CC=C(CN2C(C(NC(C3CCCCCC3)=O)=C(C)C(Br)=C2)=O)C=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CB2R PAMCannabinoid ReceptorantinociceptiveneuropathicpainInhibitorinhibitorinhibit

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Product Name:
CB2R PAM
Cat. No.:
HY-131004
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