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Cat. No.: HY-186024

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KRAS-IN-51

KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor, with its IC₅₀ for KRas G12V being 2.9 nM; K_D values are 17 (at 20°C) and 68 (at 37°C) nM. KRAS-IN-51 inhibits the phosphorylation of pERK. KRAS-IN-51 has anti-proliferative activity against SW620 and MIAPaCa-2. KRAS-IN-51 can be used for research on colorectal cancer and pancreatic cancer.

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CAS No.: 3076211-50-9
화학식: C₃₁H₃₉FN₆O₃
분자량:562.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

KRAS-IN-51 Chemical Structure

CAS No.: 3076211-50-9

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

KRas G12V

2.9 nM (IC₅₀)

All Ras Isoforms :

All ERK Isoforms :

Chemical Information

CAS No. 3076211-50-9
분자량 562.68
화학식 C₃₁H₃₉FN₆O₃
SMILES

N#CC1=C2[C@]3(CC[C@@H](C2=CC=C1N)C)CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7[C@](C)(CC7)CO)=C4CO3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shawn Cabral, et al. Spirocyclic dihydropyranopyrimidine kras inhibitors. WO2025038936.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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상품명:
CAS No.:
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KRAS-IN-51

All Ras Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KRAS-IN-51 Related Classifications

HY-186024 Related Classifications