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Cat. No.: HY-112448

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Lck-IN-6

Lck-IN-6 (Compound 12g) is a Lck inhibitor with an IC₅₀ of 3 nM. Lck-IN-6 inhibits the production of IL-2. Lck-IN-6 can be used in the research of rheumatoid arthritis and inflammatory bowel disease.

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CAS No.: 918870-43-6
화학식: C₂₄H₂₆N₆O₃
분자량:446.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lck-IN-6 Chemical Structure

CAS No.: 918870-43-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Lck

3 nM (IC₅₀)

All Src Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	0.054 μM Compound: 12g	Inhibition of IL2 production in Jurkat E6-1 T cells by ELISA Inhibition of IL2 production in Jurkat E6-1 T cells by ELISA	[PMID: 16997556]

In Vitro

Lck-IN-6 inhibits recombinant human active Lck with an IC₅₀ of 3 nM^[1].
Lck-IN-6 inhibits IL-2 production in stimulated Jurkat E6-1 human acute T cell leukemia cells with an IC₅₀ of 0.054 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 918870-43-6
분자량 446.51
화학식 C₂₄H₂₆N₆O₃
SMILES

OC1=CC=C(C(=C1)NC2=NC(=NC(OCCN3CCOCC3)=C2)N4C=NC=5C=CC=CC54)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett. 2006;16(23):5973-5977. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Lck-IN-6

All Src Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Lck-IN-6 Related Classifications

HY-112448 Related Classifications