OICR41114
OICR41114 is a WDR5 PROTAC degrader with an EC50 of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (KD increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia.
(Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-169390); Black: linker (HY-140210)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C70H83Cl2F6N9O15
- 분자량:1475.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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VHL |
OICR41114 (5.5 μM; 20 min) binds and stabilizes recombinant DCAF1 and WDR5 proteins individually, and forms a ternary complex with the combined protein mixture as measured by DSF[1].
OICR41114 (0.002-10 μM; 5 days) reduces viability of MV4-11 cells with an EC50 of 158 nM after 5 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 1475.36
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화학식 C70H83Cl2F6N9O15
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SMILES
O=C(/C=C/C1=C(C(C(N[C@H](C2=CC=C(C(Cl)=C2)F)CC(N)=O)=O)=CN1)C3=C(C=C(C=C3)Cl)F)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C4=CC=C(C(C5=CC=C(C(NC(C6=CNC(C=C6C(F)(F)F)=O)=O)=C5)N7C[C@H](N([C@H](C7)C)C)C)=C4)F)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OICR41114 Related Classifications
HY-169389 Related Classifications
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