Cat. No.: HY-103414

Raclopride

11 Cited Publications

고객리뷰

Based on 11 publication(s) in Google Scholar

Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.86%
CAS No.: 84225-95-6
화학식: C₁₅H₂₀Cl₂N₂O₃
분자량:347.24

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Raclopride Chemical Structure

CAS No.: 84225-95-6

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (11)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively^[1]^[2].

IC₅₀ & Target^[1]

D₂ Receptor

1.8 nM (Ki)

D₃ Receptor

3.5 nM (Ki)

D₄ Receptor

2400 nM (Ki)

D₁ Receptor

18000 nM (Ki)

All Dopamine Receptor Isoforms :

In Vivo

Raclopride (0.1, 0.3, or 0.6 mg/kg; IP; 30 min; albino male mice of the OF1 strain) significantly reduces time allocated to attack behavior^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 84225-95-6
Appearance Solid
분자량 347.24
화학식 C₁₅H₂₀Cl₂N₂O₃
Color White to yellow
SMILES

O=C(NC[C@H]1N(CC)CCC1)C2=C(OC)C(Cl)=CC(Cl)=C2O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (11)

All In Vivo Efficacy StudyIn Vivo Imaging

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Journal Impact Factor

Nat Commun

Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice. [Abstract]

2024 Jun 10;15(1):4947. PMID: 38858350
Neuron

Hyperexcitable VTA-mPFC dopaminergic circuit disrupts sleep spindle and mediates sleep fragmentation after chronic social defeat stress. [Abstract]

2026 May 19:S0896-6273(26)00332-6. PMID: 42161276

Raclopride purchased from MedChemExpress. Usage Cited in: Neuron. 2026 May 19:S0896-6273(26)00332-6. [Abstract]

Raclopride (1 μg/0.3 μL; ICV) alone and combined antagonist treatment both increased spindle density, with minimal effects on other spindle parameters in C57BL/6J mice.
Acta Pharmacol Sin

G protein-dependent dopamine D2 receptor signaling mediates cocaine-primed reinstatement. [Abstract]

2026 Jan 14. PMID: 41535707

Raclopride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2026 Jan 14. [Abstract]

Graphs of active nose pokes with Raclopride (0.3 mg/kg; s.c.; single dose) [i: Vehicle n = 10, Raclopride n = 11, Fgroup×session(1, 19) = 23.944, P < 0.001, two-way RM ANOVA test] treatment in cocaine-primed reinstatement test. The results showed that during the reinstatement test, active nose pokes were inhibited by Raclopride.

Raclopride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2026 Jan 14. [Abstract]

Raclopride (a D2R full antagonist, 0.3 mg/kg; s.c.; single dose; C57BL/6 J mice) significantly increased cAMP signaling in the NAcC.
Cell Rep

Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. [Abstract]

2024 Sep 10;43(9):114717. PMID: 39264811

Raclopride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Sep 10;43(9):114717. [Abstract]

Locomotor activity depicted in 5-min segments (left), total distance moved (middle), and speed (right) in the open field over a 60-min period. In the OFT, both SCH-23390 (0.125 mg/kg; i.p.; single dose; HY-19545A) and Raclopride (1 mg/kg; i.p.; single dose) reduced the hyperactivity of VTADA-shHrh2 mice. Additionally, both SCH-23390 and Raclopride decreased locomotor activity in VTADA-GFP mice during the OFT without affecting their travel speed.
Neuropsychopharmacology

Ventral subiculum promotes wakefulness through several pathways in male mice. [Abstract]

2024 Aug;49(9):1468-1480. PMID: 38734818
Transl Psychiatry

Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia. [Abstract]

2024 Feb 6;14(1):79. PMID: 38320995
J Integr Agric

2026 May 22.
Brain Res Bull

Dopaminergic neurons in the ventral periaqueductal gray projecting to the dorsal lateral septum regulate comorbid pain and anxiety. [Abstract]

2025 Aug:228:111409. PMID: 40449627

Raclopride purchased from MedChemExpress. Usage Cited in: Brain Res Bull. 2025 Aug:228:111409. [Abstract]

D2 receptor antagonist Behavioral (0.2 μg/side, 400 nL; ICV; SNI mice) reversed the alleviation of static and dynamic mechanical allodynia induced by the activation of vPAG-LSD dopaminergic projections and significantly increased the duration of spontaneous paw lifting and licking.
Insect Biochem Mol Biol

Molecular and pharmacological characterization of the dopamine receptors in the oriental fruit fly, Bactrocera dorsalis. [Abstract]

2025 May:180:104312. PMID: 40245998
J Neurosci

Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit. [Abstract]

2024 Aug 21;44(34):e0740242024. PMID: 39019613
J Pharm Biomed Anal

Integrating UPLC-MS/MS with in Silico and in Vitro Screening Accelerates the Discovery of Active Compounds in Stephania epigaea. [Abstract]

2024 Sep 15:248:116289. PMID: 38901158

용액&용해도

In Vitro:

DMSO : 100 mg/mL (287.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8799 mL

14.3993 mL

28.7985 mL

5 mM

0.5760 mL

2.8799 mL

5.7597 mL

10 mM

0.2880 mL

1.4399 mL

2.8799 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. [Content Brief]

[2]. Aguilar MA, et al. Behavioral profile of raclopride in agonistic encounters between male mice. Pharmacol Biochem Behav. 1994;47(3):753-756. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8799 mL	14.3993 mL	28.7985 mL	71.9963 mL
	5 mM	0.5760 mL	2.8799 mL	5.7597 mL	14.3993 mL
	10 mM	0.2880 mL	1.4399 mL	2.8799 mL	7.1996 mL
	15 mM	0.1920 mL	0.9600 mL	1.9199 mL	4.7998 mL
	20 mM	0.1440 mL	0.7200 mL	1.4399 mL	3.5998 mL
	25 mM	0.1152 mL	0.5760 mL	1.1519 mL	2.8799 mL
	30 mM	0.0960 mL	0.4800 mL	0.9600 mL	2.3999 mL
	40 mM	0.0720 mL	0.3600 mL	0.7200 mL	1.7999 mL
	50 mM	0.0576 mL	0.2880 mL	0.5760 mL	1.4399 mL
	60 mM	0.0480 mL	0.2400 mL	0.4800 mL	1.1999 mL
	80 mM	0.0360 mL	0.1800 mL	0.3600 mL	0.9000 mL
	100 mM	0.0288 mL	0.1440 mL	0.2880 mL	0.7200 mL

Keywords

Raclopride

11 Cited Publications

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Raclopride

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

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Neurotransmitter Receptor Compound Library

FDA Approved & Pharmacopeial Drug Library

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FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Raclopride

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (11)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Raclopride

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

FDA Approved & Pharmacopeial Drug Library

Neurodegenerative Disease-related Compound Library

Rare Diseases Drug Library

Human Metabolite Library

Heterocyclic Compound Library

Off-patent Drug Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Dopamine Receptor Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Raclopride

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (11)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Raclopride Related Classifications

HY-103414 Related Classifications