Skatole-d8
Based on 1 Customer Validation
Skatole-d8 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.90%
- CAS No.: 697807-03-7
- 화학식: C9HD8N
- 분자량:139.22
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 697807-03-7
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Unlabeled Cas 83-34-1
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Appearance Solid
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분자량 139.22
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화학식 C9HD8N
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Color White to yellow
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SMILES
[2H]C(C1=C([2H])NC2=C1C([2H])=C([2H])C([2H])=C2[2H])([2H])[2H]
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Synonyms
3-Methylindole-d8; 3-Methyl-1H-indole-d8
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (718.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Kurata K, et al. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem Biophys Res Commun. 2019 Mar 19;510(4):649-655. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.1829 mL | 35.9144 mL | 71.8288 mL | 179.5719 mL |
| 5 mM | 1.4366 mL | 7.1829 mL | 14.3658 mL | 35.9144 mL | |
| 10 mM | 0.7183 mL | 3.5914 mL | 7.1829 mL | 17.9572 mL | |
| 15 mM | 0.4789 mL | 2.3943 mL | 4.7886 mL | 11.9715 mL | |
| 20 mM | 0.3591 mL | 1.7957 mL | 3.5914 mL | 8.9786 mL | |
| 25 mM | 0.2873 mL | 1.4366 mL | 2.8732 mL | 7.1829 mL | |
| 30 mM | 0.2394 mL | 1.1971 mL | 2.3943 mL | 5.9857 mL | |
| 40 mM | 0.1796 mL | 0.8979 mL | 1.7957 mL | 4.4893 mL | |
| 50 mM | 0.1437 mL | 0.7183 mL | 1.4366 mL | 3.5914 mL | |
| 60 mM | 0.1197 mL | 0.5986 mL | 1.1971 mL | 2.9929 mL | |
| 80 mM | 0.0898 mL | 0.4489 mL | 0.8979 mL | 2.2446 mL | |
| 100 mM | 0.0718 mL | 0.3591 mL | 0.7183 mL | 1.7957 mL |
Skatole-d8 Related Classifications
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