Mersalyl  (Synonyms: Salirgan; Salurin; Salyrgan)

Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects^[1][2][3].

Mersalyl (100 µM) induces VEGF and ENO1 mRNA expression but inhibits EPO mRNA expression induced by hypoxia, DFO, or CoCl2^[2].
Mersalyl (20 µM; 5 min) is a cell-impermeant organomercurial compound that reacts with free thiol groups in mitochondrial membrane protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mersalyl (2.5-40 mg/kg; intramuscularly injection) shows diuresis effects in Rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

505.85

C₁₃H₁₆HgNNaO₆

492-18-2

Solid

White to off-white

[O-]C(COC1=C(C(NCC2OC)=[O][Hg+2]([CH2-]2)[OH-])C=CC=C1)=O.[Na+]

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Kowaltowski AJ, et al. Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition. Biochim Biophys Acta. 1997 Feb 15;1318(3):395-402.  [Content Brief]

  [2]. Agani F, et al. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol Pharmacol. 1998 Nov;54(5):749-54.  [Content Brief]

  [3]. FARAH A, et al. Histochemical studies on the site of action of mercurial diuretics. J Histochem Cytochem. 1955 Jul;3(4):271-3.  [Content Brief]