2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation
  3. Peptide-Drug Conjugates (PDCs) HSP IFNAR
  4. MPD-1

MPD-1 (Maleimide-KGDEVD-doxorubicin) is a peptide drug conjugate (PDC). MPD-1 releases Doxorubicin (HY-15142) via radiation-activated caspase-3 cleavage, triggering a cytotoxic amplification cascade at the tumor site. MPD-1 enhances CD8+ T cell tumor infiltration, and activates antigen-presenting cells. MPD-1 enables dual-trigger payload release, amplifies cytotoxicity via in situ feedback, and selectively delivers payload to tumor microenvironments via enhanced albumin metabolism and macropinocytosis. MPD-1 exhibits antitumor efficacy in mouse colorectal cancer models. MPD-1 can be used for the research of colorectal cancer.

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MPD-1

MPD-1 Chemical Structure

CAS No. : 1911555-88-8

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MPD-1 Related Antibodies

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Description

MPD-1 (Maleimide-KGDEVD-doxorubicin) is a peptide drug conjugate (PDC). MPD-1 releases Doxorubicin (HY-15142) via radiation-activated caspase-3 cleavage, triggering a cytotoxic amplification cascade at the tumor site. MPD-1 enhances CD8+ T cell tumor infiltration, and activates antigen-presenting cells. MPD-1 enables dual-trigger payload release, amplifies cytotoxicity via in situ feedback, and selectively delivers payload to tumor microenvironments via enhanced albumin metabolism and macropinocytosis. MPD-1 exhibits antitumor efficacy in mouse colorectal cancer models. MPD-1 can be used for the research of colorectal cancer[1][2].

In Vitro

MPD-1 (25-50 μM; 24 h) induces immunogenic cell death of mouse colorectal CT26.CL25 cancer cells when combined with 2 Gy radiation or activated by caspase-3 protein, as evidenced by 2.5-fold higher surface calreticulin and 8.6-fold higher extracellular HMGB1 levels compared to control[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPD-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: mouse colorectal CT26.CL25 cancer cells
Concentration: 0; 25; 50 μM
Incubation Time: 24 h
Result: Increased HMGB1 levels in the cell lysate and supernatant in a dose-dependent manner.
Increased HSP70 levels in the cell lysate at 50 μM.
In Vivo

MPD-1 (5 mg/kg; i.v.; every other day; 4 doses) inhibits tumor growth in mouse CT26 models when combined with radiation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (7-8 weeks old) subcutaneously implantated with CT26.CL25 colon carcinoma cells[2]
Dosage: 5 mg/kg
Administration: i.v.; every other day; 4 doses
Result: Induced a 2.5-fold increase in calreticulin mean fluorescence intensity (MFI) and a 5.3-fold increase in HMGB1-positive tumor tissue fraction compared to control.
Increased tumor-infiltrating lymphocytes (CD45+ cells).
Increased activation markers (CD40, CD80, CD86, CD103) on tumor dendritic cells (CD11c+).
Increased β-galactosidase (tumor antigen) MFI by 3.1-fold on CD11c+MHCII+ cells and 4.4-fold on CD11b+MHCII+ cells in tumors compared to control.
Increased β-galactosidase MFI by 4.8-fold on CD11c+MHCII+ cells and 4.1-fold on CD11b+MHCII+ cells in tumor-draining lymph nodes compared to control.
Showed negligible immune-related toxicity, with no significant reduction in lymph node/spleen weight or CD45+CD3+, CD4+, CD8+ T cell populations in lymph nodes, spleens, or blood compared to control/radiation groups.
Achieved 95.2% tumor growth inhibition and induced tumor-specific IFNγ secretion (3.4-fold higher than MPD-1+RT alone) when combined with FS nanocage and RT.
Molecular Weight

1571.55

Formula

C73H90N10O29
CAS No.
SMILES

[H][C@@]1(C[C@H](NC(OCC2=CC=C(NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCCNC(CCCCCN3C(C=CC3=O)=O)=O)NC(C)=O)=O)=O)=O)=O)=O)=O)C=C2)=O)[C@H](O)[C@H](C)O1)O[C@@H](C[C@](C(CO)=O)(CC4=C5O)O)C4=C(C(C(C6=C7OC)=O)=C5C(C6=CC=C7)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MPD-1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPD-11911555-88-8Maleimide-KGDEVD-doxorubicinMPD1MPD 1Peptide-Drug Conjugates (PDCs)HSPIFNARHeat shock proteinsInterferon-α/β receptorInterferon-alpha/beta receptorPARP inhibitiondendritic cellcathepsin Bmicrosatellite-stable colorectal cancermKRAS-mutant colorectal cancerantigen-presenting cellsCT26.CL25 cancer cellsCD8+ T cellcaspase-3/7PTEN-loss non-small cell lung cancerInhibitorinhibitorinhibit

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