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Itepekimab

(Synonyms: REGN-3500; SAR-440340)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD).

For research use only. We do not sell to patients.

  • Purity: 99.496%
  • CAS No.: 2226742-52-3
  • Molecular Weight:144.64 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Itepekimab
  • Experimental Validation Results for Itepekimab
  • Experimental Validation Results for Itepekimab
  • Itepekimab Chemical Structure
    Itepekimab Chemical Structure
CAS No.: 2226742-52-3
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Itepekimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized IL-33 Protein, Human (His, HY-P70475) can bind Itepekimab. The EC50 for this effect is 157.7 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 HUVEC cells with Itepekimab (HY-P99673, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Itepekimab Chemical Structure
    1/16
  • Itepekimab
  • Immobilized IL-33 Protein, Human (His, HY-P70475) can bind Itepekimab. The EC50 for this effect is 157.7 ng/mL.
  • Flow cytometric analysis of 1.5×106 HUVEC cells with Itepekimab (HY-P99673, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).