Nagstatin
Nagstatin is a naturally derived competitive inhibitor of N-acetyl-β-D-glucosaminidase (NAG-ase), with an IC50 of 0.0012 μg/mL and a Ki of 1.7×10-8 M against porcine-derived enzyme. Nagstatin enhances cellular immune responses in normal mice and reactivates suppressed cellular immune responses in tumor-bearing mice. Nagstatin can be used in the research of various diseases such as diabetes and leukemia.
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- CAS No.: 126844-81-3
- Formule: C12H17N3O6
- Masse moléculaire:299.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Nagstatin potently and specifically inhibits partially purified porcine kidney N-acetyl-β-D-glucosaminidase in a competitive manner, with an IC50 of 0.0012 μg/mL and a Ki of 1.7×10-8 M[1].
Nagstatin inhibits N-acetyl-β-D-glucosaminidase, with an IC50 of 5.85 nM and a Ki of 1.10 nM against the enzyme from Spodoptera litura, an IC50 of 10.6 nM and a Ki of 9.69 nM against the enzyme from Aspergillus oryzae, an IC50 of 60.6 nM and a Ki of 8.11 nM against the enzyme from Penicillium oxalicum, an IC50 of 1.83 nM and a Ki of 0.952 nM against the enzyme from human placenta, an IC50 of 1.71 nM and a Ki of 1.64 nM against the enzyme from bovine kidney, and an IC50 of 1.87 nM and a Ki of 1.41 nM against the enzyme from jack bean[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nagstatin potentiates cellular immune response in normal mice at a potency comparable to bestatin[1].
Nagstatin reactivates depressed cellular immune response in tumor-bearing mice at a potency comparable to bestatin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:250 mg/kg
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Administration:i.p.; single dose
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Result:Observed no deaths.
Chemical Information
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CAS No. 126844-81-3
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Masse moléculaire 299.28
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Formule C12H17N3O6
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SMILES
N(C(C)=O)[C@H]1C=2N([C@H](CO)[C@H](O)[C@@H]1O)C=C(CC(O)=O)N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Aoyagi T, et al. Nagstatin, a new inhibitor of N-acetyl-beta-D-glucosaminidase, produced by Streptomyces amakusaensis MG846-fF3. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1992 Sep;45(9):1404-8. [Content Brief]
[2]. Usuki H, et al. Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent beta-N-acetylglucosaminidase inhibitor. Bioorg Med Chem. 2009;17(20):7248-7253. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nagstatin Related Classifications
HY-165504 Related Classifications
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