126844-81-3
Chemical Structure
Nagstatin
- CAS No.: 126844-81-3
- Formula:C12H17N3O6
- Molecular Weight:299.28
IUPAC Name: 2-((5R,6S,7R,8S)-8-acetamido-6,7-dihydroxy-5-(hydroxymethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)acetic acid
InChIKey: XPJWMTPRJTUTBX-CZULRBLNSA-N
SMILES: N(C(C)=O)[C@H]1C=2N([C@H](CO)[C@H](O)[C@@H]1O)C=C(CC(O)=O)N2
Biological Activity: Nagstatin is a naturally derived competitive inhibitor of N-acetyl-β-D-glucosaminidase (NAG-ase), with an IC50 of 0.0012 μg/mL and a Ki of 1.7×10-8 M against porcine-derived enzyme. Nagstatin enhances cellular immune responses in normal mice and reactivates suppressed cellular immune responses in tumor-bearing mice. Nagstatin can be used in the research of various diseases such as diabetes and leukemia[1].
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Nagstatin | Nagstatin is a naturally derived competitive inhibitor of N-acetyl-β-D-glucosaminidase (NAG-ase), with an IC50 of 0.0012 μg/mL and a Ki of 1.7×10-8 M against porcine-derived enzyme. Nagstatin enhances cellular immune responses in normal mice and reactivates suppressed cellular immune responses in tumor-bearing mice. Nagstatin can be used in the research of various diseases such as diabetes and leukemia. | |||||||||||||||||||||
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Keywords
