HP211206
Based on 1 Customer Validation
(Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).
For research use only. We do not sell to patients.
- CAS No.: 3119106-17-8
- Formula: C42H55F2N9O10
- Molecular Weight:883.94
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
IC50: 181.9 nM (SARS-CoV-2 Mpro);
DC50: 621 nM (SARS-CoV-2 Mpro)[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | DC50 |
621 nM
|
Half-maximum degradation of overexpressed wild-type SARS-CoV-2 Mpro in human HEK 293T cells, determined by grayscale analysis of protein levels after 48 h of treatment with HP211206.
Half-maximum degradation of overexpressed wild-type SARS-CoV-2 Mpro in human HEK 293T cells, determined by grayscale analysis of protein levels after 48 h of treatment with HP211206.
|
38064654 |
HP211206 (1 nM-100 μM; 30 min) strongly inhibits purified SARS-CoV-2 Mpro with an IC50 of 181.9 nM and binds CRBN with an IC50 of 3.2 μM[1].
HP211206 (3 nM-10 μM; 2-48 h) induces time- and dose-dependent degradation of wild-type SARS-CoV-2 Mpro in HEK 293T cells, with a DC50 of 621 nM[1].
HP211206 (10-3000 nM; 2-48 h) induces dose-dependent degradation of drug-resistant SARS-CoV-2 Mpro mutants SARS-CoV-2 MproE166V and SARS-CoV-2 MproE166A in HEK 293T cells[1].
HP211206 (3 nM-10 μM; 2-48 h) dose-dependently and time-dependently degrades SARS-CoV-2 Mpro in transfected HEK 293T cells[1].
HP211206 (Serially diluted concentrations; 3 h) binds to GST-tagged wild-type human Cereblon with an IC50 of 3.2 μM[1].
HP211206 (0.1-100 μM; 48 h) shows no significant cytotoxicity in HEK 293T cells at concentrations up to 100 μM after 48 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK 293T cells
-
Concentration:0.1-100 μM
-
Incubation Time:48 h
-
Result:Showed no significant cytotoxicity at all tested concentrations.
-
Cell Line:HEK 293T cells transfected with pcDNA3.1(+)-SARS-CoV-2 Mpro plasmid
-
Concentration:1000 nM
-
Incubation Time:2, 6, 12, 24, 36, 48 h
-
Result:Induced degradation of transfected SARS-CoV-2 Mpro in time-dependent manners.
-
Cell Line:HEK 293T cells transfected with pcDNA3.1(+)-SARS-CoV-2 Mpro plasmid
-
Concentration:3, 10, 30, 100, 300, 1000, 3000,10000 nM
-
Incubation Time:48 h
-
Result:Induced degradation of transfected SARS-CoV-2 Mpro in dose-dependent manners.
Chemical Information
-
CAS No. 3119106-17-8
-
Appearance Solid
-
Molecular Weight 883.94
-
Formula C42H55F2N9O10
-
Color Light yellow to green yellow
-
SMILES
O=C(CCC1N2C(C(C(NCCCCCC(N(C)[C@@H](C)C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@H](C#N)C[C@H]4C(NCC4)=O)=O)C[C@@H](OC(F)F)C3)=O)=O)=O)=CC=C5)=C5C2=O)=O)NC1=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HP211206 Related Classifications
HY-170598 Related Classifications
Powered by Bioz