NOTA-NHS ester
Based on 1 publication(s) in Google Scholar
NOTA-NHS ester is a chelating agent. NOTA-NHS ester can be coupled with T140 (HY-P4810) to produce NOTA-T140. NOTA-T140 can be radiolabeled with Al[18F]. The uptake of Al[18F]NOTA-T140 in tumors is correlated with the expression level of CXCR4. Al[18F]NOTA-T140 can be used in tumor PET imaging studies. NOTA-NHS ester can be used for fluorescent labeling.
For research use only. We do not sell to patients.
- Purity: 90.0%
- CAS No.: 1338231-09-6
- Formula: C16H24N4O8
- Molecular Weight:400.38
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NOTA-NHS ester
MoreAll Radionuclide-Drug Conjugates (RDCs) Isoforms
More
Biological Activity
|
RDC Bifunctional Chelator |
CXCR4 |
NOTA-T140, generated by coupling NOTA-NHS ester with T140 (HY-P4810), can be radiolabeled with Al[18F]. The uptake of Al[18F]-labeled NOTA-T140 in tumors is correlated with the expression level of CXCR4 and can be used for tumor PET imaging studies[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1338231-09-6
-
Appearance Solid
-
Molecular Weight 400.38
-
Formula C16H24N4O8
-
Color White to light yellow
-
SMILES
O=C(O)CN1CCN(CC(ON2C(CCC2=O)=O)=O)CCN(CC(O)=O)CC1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Eur J Med Chem
Click chemistry-driven modular radionuclide labeling of HER2 nanobody: An integrated platform for diagnosis and treatment of precision oncology. [Abstract]2026 Jun 26:317:119104. PMID: 42419170
Solvent & Solubility
DMSO : ≥ 100 mg/mL (249.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Lang L, et al. Stability analysis of glutamic acid linked peptides coupled to NOTA through different chemical linkages. Mol Pharm. 2014 Nov 3;11(11):3867-74. [Content Brief]
[2]. Chen CJ, et al. 68Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging. Nucl Med Biol. 2019 Jan-Feb;68-69:22-30. [Content Brief]
[3]. Yan X, et al. Al[18F]NOTA-T140 Peptide for Noninvasive Visualization of CXCR4 Expression. Mol Imaging Biol. 2016 Feb;18(1):135-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4976 mL | 12.4881 mL | 24.9763 mL | 62.4407 mL |
| 5 mM | 0.4995 mL | 2.4976 mL | 4.9953 mL | 12.4881 mL | |
| 10 mM | 0.2498 mL | 1.2488 mL | 2.4976 mL | 6.2441 mL | |
| 15 mM | 0.1665 mL | 0.8325 mL | 1.6651 mL | 4.1627 mL | |
| 20 mM | 0.1249 mL | 0.6244 mL | 1.2488 mL | 3.1220 mL | |
| 25 mM | 0.0999 mL | 0.4995 mL | 0.9991 mL | 2.4976 mL | |
| 30 mM | 0.0833 mL | 0.4163 mL | 0.8325 mL | 2.0814 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6244 mL | 1.5610 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4995 mL | 1.2488 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4163 mL | 1.0407 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7805 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6244 mL |
NOTA-NHS ester Related Classifications
HY-W087028 Related Classifications
Powered by Bioz