1. Metabolic Enzyme/Protease
    Epigenetics
  2. Fatty Acid Synthase (FASN)
    MicroRNA
  3. Pseudoprotodioscin

Pseudoprotodioscin 

Cat. No.: HY-N0686 Purity: 98.76%
Handling Instructions

Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.

For research use only. We do not sell to patients.

Pseudoprotodioscin Chemical Structure

Pseudoprotodioscin Chemical Structure

CAS No. : 102115-79-7

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5 mg USD 99 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
20 mg USD 286 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1].

In Vitro

In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1031.18

Formula

C₅₁H₈₂O₂₁

CAS No.

102115-79-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9698 mL 4.8488 mL 9.6976 mL
5 mM 0.1940 mL 0.9698 mL 1.9395 mL
10 mM 0.0970 mL 0.4849 mL 0.9698 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PseudoprotodioscinFatty Acid Synthase (FASN)MicroRNAmiRNAABCA1proteinmRNAlevelHMGCRFASlowdensitylipoproteinreceptorcholesteroleffluxInhibitorinhibitorinhibit

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Pseudoprotodioscin
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HY-N0686
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