1. Metabolic Enzyme/Protease
    Epigenetics
  2. Fatty Acid Synthase (FAS)
    MicroRNA
  3. Pseudoprotodioscin

Pseudoprotodioscin 

Cat. No.: HY-N0686
Handling Instructions

Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.

For research use only. We do not sell to patients.

Pseudoprotodioscin Chemical Structure

Pseudoprotodioscin Chemical Structure

CAS No. : 102115-79-7

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Description

Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1].

In Vitro

In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1].

Molecular Weight

1031.18

Formula

C₅₁H₈₂O₂₁

CAS No.

102115-79-7

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Keywords:

PseudoprotodioscinFatty Acid Synthase (FAS)MicroRNAmiRNAABCA1proteinmRNAlevelHMGCRFASlowdensitylipoproteinreceptorcholesteroleffluxInhibitorinhibitorinhibit

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