Novel antiplatelet constituents from formosan moraceous plants

  • J Nat Prod. 1996 Sep;59(9):834-8. doi: 10.1021/np960376j.
C N Lin  1 ,  C M Lu ,  H C Lin ,  S C Fang ,  B J Shieh ,  M F Hsu ,  J P Wang ,  F N Ko ,  C M Teng
Affiliations
  • 1. School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
PMID: 8864236 DOI: 10.1021/np960376j
Abstract

Sixteen constituents from Formosan Moraceous Plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 microM). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.