1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Reboxetine mesylate

Reboxetine mesylate (Synonyms: FCE20124 mesylate; PNU155950E mesylate)

Cat. No.: HY-14560C Purity: 99.87%
Handling Instructions

Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM.

For research use only. We do not sell to patients.

Reboxetine mesylate Chemical Structure

Reboxetine mesylate Chemical Structure

CAS No. : 98769-84-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM[1].

IC50 & Target

Ki: 8 nM (NA reuptake)[1]

In Vitro

Reboxetine mesylate has weak affinity for muscarinic, histaminergic H1, adrenergic α1, and dopaminergic D2 receptors[1].
Reboxetine mesylate preventes the Dexamethasone-induced decreases in cell viability and proliferation rate[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells
Concentration: 0.1 μM, 1 μM, 5 μM
Incubation Time: 24 hours
Result: Prevented the Dexamethasone-induced decreases in cell viability and proliferation rate.
In Vivo

Reboxetine mesylate (30 mg/kg; i.p.) significantly decreases the immobility time in the mice depression models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Harlan-bred, male CF-1 mice (18-20 g), depression models[1]
Dosage: 3 mg/kg, 30 mg/kg
Administration: Intraperitoneal injection
Result: Significantly decreased the immobility time in the mouse tail suspension test at the dose of 30 mg/kg.
Clinical Trial
Molecular Weight

409.50

Formula

C₂₀H₂₇NO₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (305.25 mM; Need ultrasonic)

H2O : 50 mg/mL (122.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4420 mL 12.2100 mL 24.4200 mL
5 mM 0.4884 mL 2.4420 mL 4.8840 mL
10 mM 0.2442 mL 1.2210 mL 2.4420 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (268.62 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.08 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.87%

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Product Name:
Reboxetine mesylate
Cat. No.:
HY-14560C
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