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1852-49-9

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By Targets:	Endogenous Metabolite (2) Isotope-Labeled Compounds (1)
By Research Areas:	Endocrinology (1) Metabolic Disease (1)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W040047

Pregnanediol 3-glucuronide	Endogenous Metabolite	Metabolic Disease
Pregnanediol 3-glucuronide is the main terminal metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is the metabolite of Progesterone produced in the liver through hydroxylation and glucuronidation, with high hydrophilicity and easy excretion through urine. A decrease in the level of Pregnanediol 3-glucuronide is associated with an increased risk of thyroid cancer, while an increase is associated with the state of pregnancy. Pregnanediol 3-glucuronide is of great significance in the monitoring of female reproductive health, pregnancy assessment, and the diagnosis of endocrine diseases .

HY-W040047S

Pregnanediol 3-glucuronide-13C5	Endogenous Metabolite Isotope-Labeled Compounds	Endocrinology
Pregnanediol 3-glucuronide is the main end-metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is a metabolite of Progesterone formed by hydroxylation and glucuronidation in the liver, with high hydrophilicity and easy excretion through urine. Pregnanediol 3-glucuronide excretion rate of ≥ 9 μmol/24 h can serve as biochemical evidence of ovulation. Pregnanediol 3-glucuronide reflects the quality of the luteal phase, and a level of < 7 μmol/24 h may indicate anovulation or luteal insufficiency. Pregnanediol 3-glucuronide holds significant importance in monitoring female reproductive health, assessing pregnancy, and diagnosing endocrine disorders.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040047

Pregnanediol 3-glucuronide	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
Pregnanediol 3-glucuronide is the main terminal metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is the metabolite of Progesterone produced in the liver through hydroxylation and glucuronidation, with high hydrophilicity and easy excretion through urine. A decrease in the level of Pregnanediol 3-glucuronide is associated with an increased risk of thyroid cancer, while an increase is associated with the state of pregnancy. Pregnanediol 3-glucuronide is of great significance in the monitoring of female reproductive health, pregnancy assessment, and the diagnosis of endocrine diseases .

Cat. No.	Product Name	Chemical Structure

HY-W040047S

Pregnanediol 3-glucuronide-13C5
Pregnanediol 3-glucuronide is the main end-metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is a metabolite of Progesterone formed by hydroxylation and glucuronidation in the liver, with high hydrophilicity and easy excretion through urine. Pregnanediol 3-glucuronide excretion rate of ≥ 9 μmol/24 h can serve as biochemical evidence of ovulation. Pregnanediol 3-glucuronide reflects the quality of the luteal phase, and a level of < 7 μmol/24 h may indicate anovulation or luteal insufficiency. Pregnanediol 3-glucuronide holds significant importance in monitoring female reproductive health, assessing pregnancy, and diagnosing endocrine disorders.

Pregnanediol 3-glucuronide-13C5

Pregnanediol 3-glucuronide is the main end-metabolite of Progesterone (HY-N0437). Pregnanediol 3-glucuronide is a metabolite of Progesterone formed by hydroxylation and glucuronidation in the liver, with high hydrophilicity and easy excretion through urine. Pregnanediol 3-glucuronide excretion rate of ≥ 9 μmol/24 h can serve as biochemical evidence of ovulation. Pregnanediol 3-glucuronide reflects the quality of the luteal phase, and a level of < 7 μmol/24 h may indicate anovulation or luteal insufficiency. Pregnanediol 3-glucuronide holds significant importance in monitoring female reproductive health, assessing pregnancy, and diagnosing endocrine disorders.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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1852-49-9

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products