1 Result for "

215183-03-2

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "215183-03-2" in MCE Product Catalog:

Cat. No.: HY-156696
CAS No.: 215183-03-2
Research Areas:  

Metabolic Disease

S3226 is a highly selective NHE-3 inhibitor (IC50<1 μM) that specifically blocks NHE-3-mediated sodium transport. S3226 significantly inhibits blastocyst formation and expansion in mouse embryos, and reduces fluid and electrolyte reabsorption in rat proximal tubules in a dose-dependent manner. S3226 effectively alleviates ischemia-induced acute renal failure by improving renal function parameters, reducing renal tubular injury and restoring intracellular pH homeostasis, without interfering with the normal tubuloglomerular feedback response. S3226 is widely used in studies of acute renal failure and related pathological mechanisms .
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