1 Result for "

3061498-57-2

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "3061498-57-2" in MCE Product Catalog:

Cat. No.: HY-158342
CAS No.: 3061498-57-2
Purity:  99.82%
Target:  

PROTACs YAP

Research Areas:  

Cancer

PROTAC TEAD degrader-1 is a TEAD2 degrader and antiproliferative agent with selective activity toward TEAD2 relative to other TEAD family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for TEAD2 degradation; disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF. PROTAC TEAD degrader-1 can be used for the research of NF2-deficient cancer .
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