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1 Result for "
4-oxo DHA
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "4-oxo DHA" in MCE Product Catalog:
Cat. No.: HY-134997
CAS No.: 845673-74-7
Synonyms: 4-oxo DHA
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of Docosahexaenoic acid (HY-B2167) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.
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