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4.96

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43

Inhibitors & Agonists

6

Fluorescent Dyes

1

Biochemical Assay Reagents

1

Natural
Products

3

Antibodies

20

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-80002
    BMX-IN-1
    5+ Cited Publications

    BMX kinase inhibitor

    		 Btk BMX Kinase Cancer
    BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys 496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
    BMX-IN-1
  • HY-D1078
    5(6)-Carboxy-2',7'-dichlorofluorescein diacetate

    		Fluorescent Dye Reactive Oxygen Species (ROS) P-glycoprotein Others
    5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm) .
    5(6)-Carboxy-2',7'-dichlorofluorescein diacetate
  • HY-158039
    YCH2823

    		Deubiquitinase Apoptosis Cancer
    YCH2823 is an inhibitor of USP7 (IC50 = 49.6 nM; Kd = 0.117 μM). YCH2823 shows significant efficacy in inhibiting TP53 wild-type and mutant tumors, with approximately 5-fold higher potency than FT671. YCH2823 induce apoptosis. YCH2823 synergistic effects with mTOR inhibitors .
    YCH2823
  • HY-131010
    Flutax-2 (5/6-mixture)

    		Fluorescent Dye Microtubule/Tubulin Cancer
    Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .
    Flutax-2 (5/6-mixture)
  • HY-163372
    PROTAC HPK1 Degrader-1

    		PROTACs MAP4K Cancer
    PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling .
    PROTAC HPK1 Degrader-1
  • HY-16637D
    Folic acid disodium
    20+ Cited Publications

    Vitamin B9 disodium; Vitamin M disodium

    		 Endogenous Metabolite DNA/RNA Synthesis Others Neurological Disease Cancer
    Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 5 g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .
    Folic acid disodium
  • HY-D2874
    6-AF488 tyramide

    		Fluorescent Dye Others
    6-AF488 tyramide is a bright, green fluorescent dye (Ex=496 nm, Em=524 nm). 6-AF488 tyramide is utilized as reporter fluorescent substrate of horseradish peroxidase (HRP)-catalyzed deposition for tyramide signal amplification (TSA). 5-FITC tyramide can be used for multiplex immunohistochemistry (mIHC) .
    6-AF488 tyramide
  • HY-162161
    Flutax-2

    		Fluorescent Dye Microtubule/Tubulin Cancer
    Flutax-2 is an active fluorescent derivative of Paclitaxel (HY-B0015) that binds to polymerized αβ-tubulin dimers. Flutax-2 is applicable for imaging microtubules in live cells, isolated cytoskeletons and parasites (Ex/Em=496/526 nm) .
    Flutax-2
  • HY-122140
    ACG548B

    		Cholinesterase (ChE) Neurological Disease
    ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase). ACG548B can be uesd for the study of myasthenia gravis and neuromuscular blockade .
    ACG548B
  • HY-19432
    UBP-282

    		iGluR Neurological Disease
    UBP-282 is a potent, selective and competitive AMPA and kainate receptor antagonist. UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC50 value of 10.3 μM. UBP-282 antagonizes kainate-induced depolarisations of dorsal roots with a pA2 value of 4.96 .
    UBP-282
  • HY-149666
    BMS-496

    		DGK Cancer
    BMS-496 is adualDGKα/ζlipid kinase inhibitor, with theIC50of 0.09 (DGKα) and 0.006 μM (DGKζ) .
    BMS-496
  • HY-U00253
    KP496

    		Leukotriene Receptor Prostaglandin Receptor Inflammation/Immunology Endocrinology
    KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.
    KP496
  • HY-178191
    SGC stimulator 1

    		Guanylate Cyclase Autophagy AMPK TGF-β Receptor Cardiovascular Disease
    sGC stimulator 1 is a carbonyl sulfide (COS)/H2S-donor hybrid soluble guanylyl cyclase (sGC) stimulator (EC50 = 496 nM). sGC stimulator 1 exhibits a well-characterized H2S-releasing property. sGC stimulator 1 reduces fibrosis in TGF-β1-treated cardiac fibroblasts by increasing cGMP and H2S levels. sGC stimulator 1 can exert anti-fibrotic effects by activating sGC and increasing H2S. sGC stimulator 1 can be used for the study of heart failure (HF) .
    SGC stimulator 1
  • HY-R01474
    hsa-miR-496 mimic

    		MicroRNA Cancer
    hsa-miR-496 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-496 mimic
    hsa-miR-496 mimic
  • HY-R03227
    mmu-miR-496b mimic

    		MicroRNA Cancer
    mmu-miR-496b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-496b mimic
    mmu-miR-496b mimic
  • HY-R03226
    mmu-miR-496a-5p mimic

    		MicroRNA Cancer
    mmu-miR-496a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-496a-5p mimic
    mmu-miR-496a-5p mimic
  • HY-R01474A
    hsa-miR-496 agomir

    		MicroRNA Cancer
    hsa-miR-496 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-496 agomir
    hsa-miR-496 agomir
  • HY-R04496
    rno-miR-496-5p mimic

    		MicroRNA Cancer
    rno-miR-496-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    rno-miR-496-5p mimic
    rno-miR-496-5p mimic
  • HY-R04495
    rno-miR-496-3p mimic

    		MicroRNA Cancer
    rno-miR-496-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    rno-miR-496-3p mimic
    rno-miR-496-3p mimic
  • HY-16729A
    Relenopride hydrochloride

    YKP10811 hydrochloride

    		 5-HT Receptor Inflammation/Immunology
    Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A (Ki=600 nM) and 5-HT2B receptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility .
    Relenopride hydrochloride
  • HY-146294
    COX-2/5-LOX-IN-1

    		COX Inflammation/Immunology
    COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively .
    COX-2/5-LOX-IN-1
  • HY-W953524
    CRBN ligand-496

    		Ligands for E3 Ligase Cancer
    CRBN ligand-496 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-496 can be linked to a target protein ligand via a linker to form a PROTAC.
    CRBN ligand-496
  • HY-168081
    PD-1/PD-L1-IN-52

    		PD-1/PD-L1 Cancer
    PD-1/PD-L1-IN-52 (Compound III-5) is an orally active PD-1/PD-L1 inhibitor that blocks the interaction between PD-1 and PD-L1, with an IC50 of 109.9 nM. PD-1/PD-L1-IN-52 exhibits antitumor activity in a C57BL/6 mouse xenograft model implanted with human PD-1-expressing MC38 colon cancer cells, with a TGI of 49.6% .
    PD-1/PD-L1-IN-52
  • HY-147826
    EGFR-IN-60

    		EGFR Apoptosis Cancer
    EGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFR WT, EGFR T790M, EGFR L858R and JAK3 with IC50s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFR T790M mutation (IC50=1.32 µM) over A431 cells overexpressing EGFR WT (IC50=4.96 µM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio .
    EGFR-IN-60
  • HY-145258
    GABAA receptor agent 6

    		GABA Receptor Neurological Disease
    GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability .
    GABAA receptor agent 6
  • HY-RI01474
    hsa-miR-496 inhibitor

    		MicroRNA Cancer
    hsa-miR-496 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-496 inhibitor
    hsa-miR-496 inhibitor
  • HY-RI03227
    mmu-miR-496b inhibitor

    		MicroRNA Cancer
    mmu-miR-496b inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-496b inhibitor
    mmu-miR-496b inhibitor
  • HY-RI03226
    mmu-miR-496a-5p inhibitor

    		MicroRNA Cancer
    mmu-miR-496a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-496a-5p inhibitor
    mmu-miR-496a-5p inhibitor
  • HY-R03227A
    mmu-miR-496b agomir

    		MicroRNA Cancer
    mmu-miR-496b agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-496b agomir
    mmu-miR-496b agomir
  • HY-RI01474A
    hsa-miR-496 antagomir

    		MicroRNA Cancer
    hsa-miR-496 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-496 antagomir
    hsa-miR-496 antagomir
  • HY-RI03227A
    mmu-miR-496b antagomir

    		MicroRNA Cancer
    mmu-miR-496b antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-496b antagomir
    mmu-miR-496b antagomir
  • HY-R03226A
    mmu-miR-496a-5p agomir

    		MicroRNA Cancer
    mmu-miR-496a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-496a-5p agomir
    mmu-miR-496a-5p agomir
  • HY-RI03226A
    mmu-miR-496a-5p antagomir

    		MicroRNA Cancer
    mmu-miR-496a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-496a-5p antagomir
    mmu-miR-496a-5p antagomir
  • HY-RI04496
    rno-miR-496-5p inhibitor

    		MicroRNA Cancer
    rno-miR-496-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    rno-miR-496-5p inhibitor
    rno-miR-496-5p inhibitor
  • HY-RI04495
    rno-miR-496-3p inhibitor

    		MicroRNA Cancer
    rno-miR-496-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    rno-miR-496-3p inhibitor
    rno-miR-496-3p inhibitor
  • HY-R04495A
    rno-miR-496-3p agomir

    		MicroRNA Cancer
    rno-miR-496-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    rno-miR-496-3p agomir
    rno-miR-496-3p agomir
  • HY-R04496A
    rno-miR-496-5p agomir

    		MicroRNA Cancer
    rno-miR-496-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    rno-miR-496-5p agomir
    rno-miR-496-5p agomir
  • HY-RI04495A
    rno-miR-496-3p antagomir

    		MicroRNA Cancer
    rno-miR-496-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    rno-miR-496-3p antagomir
    rno-miR-496-3p antagomir
  • HY-RI04496A
    rno-miR-496-5p antagomir

    		MicroRNA Cancer
    rno-miR-496-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    rno-miR-496-5p antagomir
    rno-miR-496-5p antagomir
  • HY-D3050
    5(6)-carbonylated rhodamine 110 X NHS ester

    		Fluorescent Dye Others
    5(6)-carbonylated rhodamine 110 X NHS ester is a reactive ester fluorescent reagent based on 5(6)-carbonylated rhodamine 110 X. NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 496/522 nm).
    5(6)-carbonylated rhodamine 110 X NHS ester
  • HY-D0988A
    R-Phycoerythrin (concentrated solution)

    R-PE (concentrated solution)

    		 Fluorescent Dye Apoptosis Others
    R-Phycoerythrin (R-PE) (concentrated solution) is found in Heterosiphonia japonica. R-Phycoerythrin (concentrated solution) is an orange-red fluorescent probe with α, β, and γ subunits. R-Phycoerythrin (concentrated solution) can be used in photodynamic therapy (PDT) to induce apoptosis in tumor cells. R-Phycoerythrin (concentrated solution) can be used in fluorescence microscopy, flow cytometry, and immunofluorescence analysis (Ex/Em = 496/578 nm) .
    R-Phycoerythrin (concentrated solution)
  • HY-D0988B
    R-Phycoerythrin ammonium sulfate precipitate

    R-PE ammonium sulfate precipitate

    		 Fluorescent Dye Apoptosis Others
    R-Phycoerythrin (R-PE) (ammonium sulfate precipitate) is found in Heterosiphonia japonica. R-Phycoerythrin (ammonium sulfate precipitate) is an orange-red fluorescent probe with α, β, and γ subunits. R-Phycoerythrin (concentrated solution) can be used in photodynamic therapy (PDT) to induce apoptosis in tumor cells. R-Phycoerythrin (ammonium sulfate precipitate) can be used in fluorescence microscopy, flow cytometry, and immunofluorescence analysis (Ex/Em = 496/578 nm) .
    R-Phycoerythrin ammonium sulfate precipitate
  • HY-182902
    IHMT-15137

    		BMX Kinase Apoptosis Cancer
    IHMT-15137 is a BMX inhibitor with an IC50 of 26.97 nM. IHMT-15137 covalently binds to BMX Cys496 within the ATP-binding pocket, inhibits BMX phosphorylation at Tyr566, and disrupts the BMX-ERK1/2-Cyclin D1/CDK4/6-E2F1 signaling axis. IHMT-15137 reduces E2F1 protein stability via decreased Ser332/337 phosphorylation, increased ubiquitination, and ubiquitin-proteasome pathway degradation. IHMT-15137 induces cell cycle arrest, apoptosis, DNA damage, and suppresses cell migration and invasion. IHMT-15137 can be used for the research of small cell lung cancer .
    IHMT-15137

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