1. GPCR/G Protein
  2. Leukotriene Receptor
    Prostaglandin Receptor
  3. KP496

KP496 

Cat. No.: HY-U00253 Purity: 95.81%
Handling Instructions

KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.

For research use only. We do not sell to patients.

KP496 Chemical Structure

KP496 Chemical Structure

CAS No. : 217799-03-6

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5 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
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Description

KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.

IC50 & Target[1]

LTD4

 

TXA2 Receptor

 

In Vivo

KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively[1]. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

692.27

Formula

C₃₁H₃₄ClN₃O₇S₃

CAS No.

217799-03-6

SMILES

O=C(O)C1=CC=CC=C1S(=O)(N(CCCCNS(=O)(C2=CC=C(Cl)C=C2)=O)CC3=CC=CC(OCC4=NC(C(C)C)=CS4)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
Animal Administration
[1]

Male mice (9 weeks old, 33 to 42g are used) BLM solution (15 mg/mL) is intravenously injected into mice (0.1 mL/10 g of body weight) on day 0. Mice are sacrificed on day 7 or 21. They are exposed to an aerosol of KP496 (KP-496) solution (0.5%) for 30 min using a pressure nebulizer 1 h before and 3 h after BLM-injection on day 0. From day 1 to the day before sacrificed, mice are exposed to KP496 (0.5%) for 30 min morning and evening[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

KP496KP 496KP-496Leukotriene ReceptorProstaglandin ReceptorInhibitorinhibitorinhibit

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