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Cat. No.: HY-162161

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Flutax-2

Flutax-2 is an active fluorescent derivative of Paclitaxel (HY-B0015) that binds to polymerized αβ-tubulin dimers. Flutax-2 is applicable for imaging microtubules in live cells, isolated cytoskeletons and parasites (Ex/Em=496/526 nm).

For research use only. We do not sell to patients.

CAS No.: 301844-13-3
Formula: C₇₁H₆₄F₂N₂O₂₁
Molecular Weight:1319.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Flutax-2 Chemical Structure

CAS No.: 301844-13-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Flutax-2 (75-750 nM; 16 h) binds to microtubules in 1A9, PTX10, and A549 cells, as demonstrated by fluorescence signal intensity and the quantification of labeled microtubules^[1].
The microtubule-binding activity of Flutax-2 (75 nM; 16 h) is significantly enhanced in HDAC6-wt NIH-3T3 cells treated in combination with Lonafarnib (HY-15136)^[1].
Flutax-2 (1 μM; 40 min at 37°C) specifically labels microtubule-containing structures (axostyle, centrosome, anterior flagella) in live Trichomonas vaginalis ATCC strains 30236 and 30238^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 301844-13-3
Molecular Weight 1319.27
Formula C₇₁H₆₄F₂N₂O₂₁
SMILES

O=C1OC2(C3=CC(F)=C(O)C=C3OC4=CC(O)=C(F)C=C42)C5=CC=C(C(N[C@@H](C)C(O[C@@H]6[C@@]7([C@@]([C@@H]([C@]8(C(C)(C([C@H](C7=O)OC(C)=O)=C([C@H](C8)OC([C@H](O)[C@H](C9=CC=CC=C9)NC(C%10=CC=CC=C%10)=O)=O)C)C)O)OC(C%11=CC=CC=C%11)=O)([H])[C@]%12([C@@](OC%12)([H])C6)OC(C)=O)C)=O)=O)C=C51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marcus AI, et al. Farnesyltransferase inhibitors reverse taxane resistance. Cancer Res. 2006;66(17):8838-8846. [Content Brief]

[2]. Lecke SB, et al. Trichomonas vaginalis: microtubule cytoskeleton distribution using fluorescent taxoid. Exp Parasitol. 2002;102(2):113-116. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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