2. Cell Cycle/DNA Damage Apoptosis
  3. Deubiquitinase Apoptosis
  4. YCH2823

YCH2823 is an inhibitor of USP7 (IC50 = 49.6 nM; Kd = 0.117 μM). YCH2823 shows significant efficacy in inhibiting TP53 wild-type and mutant tumors, with approximately 5-fold higher potency than FT671. YCH2823 induce apoptosis. YCH2823 synergistic effects with mTOR inhibitors.

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YCH2823 Chemical Structure

YCH2823 Chemical Structure

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YCH2823 Related Antibodies

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Description

YCH2823 is an inhibitor of USP7 (IC50 = 49.6 nM; Kd = 0.117 μM). YCH2823 shows significant efficacy in inhibiting TP53 wild-type and mutant tumors, with approximately 5-fold higher potency than FT671. YCH2823 induce apoptosis. YCH2823 synergistic effects with mTOR inhibitors[1].

IC50 & Target

USP7

49.6 nM (IC50)

In Vitro

YCH2823 interacts directly with USP7 with high affinity and effectively inhibits its enzymatic activity. Potentially low toxicity to IMR-90 cells[1].
YCH2823 (0-10 μM; 72 h or 5 days) demonstrates significant dose-dependent inhibition of cell proliferation across different cancer cell lines. High sensitivity to TP53 wild-type, mutant. [1].
YCH2823 (0-1 μM; 1-48 h ) affects protein stability and cell cycle regulation. It leads to decrease in MDM2 protein levels within 1 h and elevation of p53 and p21 levels in LNCaP cells. In MM.1S cells, although p53 protein levels do not change significantly, p21 levels are independently higher, indicating a possible p53-independent pathway for p21 induction.n the TP53 mutant Capan-1 resulted in a significant decrease in Rad18 and DNMT1 proteins, along with an increase in p21 levels[1].
YCH2823 (0-1 μM; 6-48 h ) causes up-regulation of BCL6 protein and mRNA. It induces apoptosis by increasing the proportion of cells in G1 phase in CHP212 cells and IMR-32 cells. The manipulations of DNMT1, p53, and p21 has no impact on the YCH2823-induced upregulation of BCL6[1].
YCH2823 with Rapamycin (HY-10219) or Ridaforolimus (HY-50908) results in a synergistic effect, where is more effective than either agent alone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YCH2823 Related Antibodies

Apoptosis Analysis[1]

Cell Line: CHP-212 cells
Concentration: 0, 0.03, 0.1, 0.3, 1 μM
Incubation Time: 48 h
Result: Induced significant apoptosis, demonstrating YCH2823’s capacity to induce programmed cell death.

Western Blot Analysis[1]

Cell Line: CHP212 cells
Concentration: 0, 0.1, 0.3, 1 μM
Incubation Time: 6-48 h
Result: YCH2823 led to a significant upregulation of BCL6 protein and mRNA, observable as early as 6 hours post-treatment and sustained over time. This suggests that YCH2823 may impact transcriptional regulation related to BCL6. Also led the decreases in Rad18 and DNMT1 suggesting effects on DNA repair mechanisms.
Molecular Weight

500.59

Formula

C29H32N4O4
SMILES

COC1=CC=C(C=C1)N2C=CC3=C2N=CN(C3=O)CC4(CCN(CC4)C(C[C@H](C5=CC=CC=C5)C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YCH2823 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YCH2823YCH 2823YCH-2823DeubiquitinaseApoptosisDUBsUSP7 inhibitorFT671P53BCL6mTOR inhibitorcancerInhibitorinhibitorinhibit

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