1 Result for "

433953-86-7

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "433953-86-7" in MCE Product Catalog:

Cat. No.: HY-173572
CAS No.: 433953-86-7
Target:  

Sirtuin Autophagy

Research Areas:  

Cardiovascular Disease

SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models .
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