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Results for "

8-Hydroxyquinoline

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payloads (1) Antibiotic (6) Apoptosis (1) ATF6 (1) Bacterial (6) Biochemical Assay Reagents (4) Caspase (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Metabolite (1) Environmental Pollutants (3) Fungal (2) Influenza Virus (1) JNK (1) NF-κB (2) p38 MAPK (1) Parasite (7) Phosphodiesterase (PDE) (1) Phospholipase (1) Proteasome (2) Reference Standards (5) SARS-CoV (2) Somatostatin Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Endocrinology (1) Infection (11) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

By Targets:

ADC Payloads (1)

Antibiotic (6)

Apoptosis (1)

ATF6 (1)

Bacterial (6)

Biochemical Assay Reagents (4)

Caspase (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Metabolite (1)

Environmental Pollutants (3)

Fungal (2)

Influenza Virus (1)

JNK (1)

NF-κB (2)

p38 MAPK (1)

Parasite (7)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

Proteasome (2)

Reference Standards (5)

SARS-CoV (2)

Somatostatin Receptor (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (11)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1005

*8-Hydroxyquinoline* 1 Publications Verification 8-Quinolinol	Environmental Pollutants Antibiotic Bacterial	Cancer
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .

HY-17365

Octreotide acetate 15+ Cited Publications SMS 201-995 acetate	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-B0295

Chloroxine 2 Publications Verification	Bacterial Antibiotic Parasite	Infection
Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp .

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payloads	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-B1400

Diiodohydroxyquinoline 2 Publications Verification Iodoquinol; 5,7-Diiodo-8-Hydroxyquinoline; 5,7-Diiodo-8-quinolinol	Environmental Pollutants Parasite SARS-CoV	Infection Inflammation/Immunology
Diiodohydroxyquinoline (Iodoquinol, 5,7-Diiodo-8-hydroxyquinoline, 5,7-Diiodo-8-quinolinol) has an orally active and satisfactory antiparasitic properties. Diiodohydroxyquinoline exhibits mutagenic potential in mice and potent anti-SARS-CoV-2 activity with an EC₅₀ value of 1.38 μM in VeroE6 cells. Diiodohydroxyquinoline's antimutagen is ascorbic acid. Diiodohydroxyquinoline is promising for research in inflammationin, testinal amebiasis, amebic liver abscess and chronic nonspecific diarrheas .

HY-B1212

Broxyquinoline 2 Publications Verification DibromoHydroxyquinoline; 5,7-Dibromo-8-Hydroxyquinoline	Parasite Influenza Virus	Infection
Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC₅₀ of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP₁ with an IC₅₀ of 64.9 μM. CpACBP₁ is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases .

HY-W001023

5-Amino-8-hydroxyquinoline 5A8HQ; 5AHQ	Proteasome NF-κB	Cancer
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline can be used for the research of cancer, such as leukemia .

HY-W012037

8-Hydroxyquinoline hemisulfate 1 Publications Verification 8-Quinolinol hemisulfate	Environmental Pollutants Antibiotic Bacterial	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-W012037R

8-Hydroxyquinoline hemisulfate (Standard) 8-Quinolinol hemisulfate (Standard)	Reference Standards Bacterial Antibiotic	Infection
8-Hydroxyquinoline (hemisulfate) (Standard) is the analytical standard of 8-Hydroxyquinoline (hemisulfate). This product is intended for research and analytical applications. 8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-W008992

Quinolin-8-ol sulfate hydrate 8-Hydroxyquinoline sulfate hydrate	Biochemical Assay Reagents	Others
Quinolin-8-ol sulfate hydrate is an organic compound commonly used in dyes and as a raw material for chemical analysis. It can cooperate with metal ions to form dyes, and is widely used in the fields of dyes, printing and textile manufacturing. In addition, the compound also has good toxicity and biocompatibility, and is also used in some medical fields.

HY-B1005R

8-Hydroxyquinoline (Standard) 8-Quinolinol (Standard)	Reference Standards Bacterial Antibiotic	Cancer
8-Hydroxyquinoline (Standard) is the analytical standard of 8-Hydroxyquinoline. This product is intended for research and analytical applications. 8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .

HY-W016840

8-Hydroxyquinoline-2-carbaldehyde	Biochemical Assay Reagents	Others
8-Hydroxyquinoline-2-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-B1400R

Diiodohydroxyquinoline (Standard) Iodoquinol (Standard); 5,7-Diiodo-8-Hydroxyquinoline (Standard); 5,7-Diiodo-8-quinolinol (Standard)	Reference Standards Parasite SARS-CoV	Infection Inflammation/Immunology
Diiodohydroxyquinoline (Standard) is the analytical standard of Diiodohydroxyquinoline. This product is intended for research and analytical applications. Diiodohydroxyquinoline (Iodoquinol, 5,7-Diiodo-8-hydroxyquinoline, 5,7-Diiodo-8-quinolinol) has an orally active and satisfactory antiparasitic properties. Diiodohydroxyquinoline exhibits mutagenic potential in mice and potent anti-SARS-CoV-2 activity with an EC50 value of 1.38 μM in VeroE6 cells. Diiodohydroxyquinoline's antimutagen is ascorbic acid. Diiodohydroxyquinoline is promising for research in inflammationin, testinal amebiasis, amebic liver abscess and chronic nonspecific diarrheas .

HY-145482R

W36017 (Standard)	Drug Metabolite Reference Standards	Neurological Disease
8-Hydroxyquinoline (hemisulfate) (Standard) is the analytical standard of 8-Hydroxyquinoline (hemisulfate). This product is intended for research and analytical applications. 8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-W288349

8-Quinolinyl β-D-glucopyranoside	Biochemical Assay Reagents	Others
8-Quinolinyl β-D-glucopyranoside is an 8-hydroxyquinoline glucoconjugate that can be cleaved in vitro by β-glucosidase .

HY-B0295R

Chloroxine (Standard)	Reference Standards Bacterial Antibiotic Parasite	Infection
Chloroxine (Standard) is the analytical standard of Chloroxine. This product is intended for research and analytical applications. Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-W001023A

*5-Amino-8-hydroxyquinoline* dihydrochloride** 5A8HQ dihydrochloride; 5AHQ dihydrochloride	Proteasome NF-κB	Cancer
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) dihydrochloride is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline dihydrochloride can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline dihydrochloride can be used for the research of cancer, such as leukemia .

HY-W051530

8-Methoxyquinoline	Drug Derivative	Cancer
8-Methoxyquinoline is a structural analogue of 8-hydroxyquinoline (HY-B1005). 8-Methoxyquinoline does not bind copper. 8-Methoxyquinoline could neither inhibit the chymotrypsin-like activity of the proteasome in breast cancer cell cultures nor induce cancer cell death. 8-Methoxyquinoline can be used in the research of breast cancer .

HY-179044

MKK7-JNK activator 1	p38 MAPK JNK Caspase Apoptosis	Cancer
MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production). MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC) .

HY-P11783

Surfactin C2	Fungal	Infection
Surfactin C2 is a lipopeptide produced by Bacillus subtilis A18 with antifungal activity. Surfactin C2 acts against Heterobasidion annosum and Heterobasidion parviporum. Surfactin C2 exerts its activity mainly through membrane‑active effects to disrupt fungal cell structures and inhibit mycelial growth. Surfactin C2 can be used for the research of butt rot and root rot of conifers .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name	Type