521-74-4
Chemical Structure
Broxyquinoline
Synonym(s): Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline
- CAS. Nr.: 521-74-4
- Formula:C9H5Br2NO
- Molecular Weight:302.95
IUPAC Name: 5,7-dibromoquinolin-8-ol
InChIKey: ZDASUJMDVPTNTF-UHFFFAOYSA-N
SMILES: OC1=C2N=CC=CC2=C(Br)C=C1Br
Biological Activity: Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Broxyquinoline | 99.74% | Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases. | ||||||||||||||||||||
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- [1]. Shuofeng Yuan, et al. Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. Viruses. 2019 Apr 25;11(4):385. [Content Brief]
- [2]. Fritzler JM, et al. Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP). J Antimicrob Chemother. 2012 Mar;67(3):609-17. [Content Brief]
Keywords
