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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
926
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "926" in MCE Product Catalog:
3
3 Cited Publications
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JMS-053 is an efficient and reversible PTP4A3 inhibitor, with an IC50 value of 18 nM.
JMS-053 demonstrates broad PTP4A inhibitory activity with IC50s of 50 nM and 53 nM for PTP4A1 and PTP4A2, respectively. JMS-053 exhibits IC50 values of 92.6 nM and 207.6 nM for CDC25B and DUSP3, respectively. JMS-053 can effectively inhibit the activity of PTP4A3, inhibit tumor cell proliferation and migration through multiple mechanisms such as interfering with RhoA and STAT3/p38 signaling pathway. JMS-053 can be used for the study of cancers such as ovarian cancer, breast cancer and colon cancer .
Cat. No.: HY-L926
2,109 compounds
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors.
This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.
Cat. No.: HY-16510
CAS No.: 1184136-10-4
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UNC926 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM .
Cat. No.: HY-160259
CAS No.: 2353417-86-2
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VEGFR-2-IN-39 (PROTAC-5) is a PROTAC targeting VEGFR-2 (IC50: 208.6 nM). VEGFR-2-IN-39 has low toxicity.VEGFR-2-IN-39 inhibits the proliferation of EA.hy926, one of HUVECs, in a concentration-dependent manner, with an IC50 of 38.65 µM .
Cat. No.: HY-16510A
CAS No.: 1782573-49-2
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UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM .
Cat. No.: HY-105140
CAS No.: 169673-60-3
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CPA 926 is a prodrug of Esculetin (HY-N0284) and is orally active. CPA 926 can inhibit the production of MMP in cartilage explants. CPA 926 can be used for the research of inflammation, such as experimental osteoarthritis .
Cat. No.: HY-122006
CAS No.: 384361-79-9
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NPD926 is a small molecule that targets glutathione and induces cancer cell death. NPD926 causes cellular glutathione depletion and subsequent generation of reactive oxygen species (ROS), thereby sensitizing fibroblasts to Xc- system inhibitors. NPD926 is a ROS inducer with anticancer activity. .
Cat. No.: HY-175972
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CAI/II-IN-12 is a potent and hCAI (IC50 = 7.12 μM, Ki = 9.26 μM) and hCAII (IC50 = 10.62 μM, Ki = 11.72 μM) dual inhibitor. CAI/II-IN-12 has a strong affinity for the active sites of CYP17A1, hCAI, and hCAII enzymes. Compound CAI/II-IN-12 exhibits rapid conformational stabilization, particularly in the CYP17A1 complex. CAI/II-IN-12 can be used for the study of prostate cancer therapy and glaucoma .
Cat. No.: HY-116605
CAS No.: 1346704-13-9
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GSK926 (compound 3) is a selective histone lysine methyltransferase EZH2 inhibitor (IC50=0.02 μM; Ki=7.9 nM), with SAM-competitive and cell-active properties. GSK926 can be used in cancer research .
Cat. No.: HY-173064
DS-103 is an inhibitor for HDAC that inhibits HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8 with IC50s of 0.029, 0.123, 0.022, 0.367 and 9.26 μM, respectively. DS-103 inhibits Plasmodium falciparum 3D7 with IC50 of 5.08 μM. DS-103 exhibits cytotoxicity in cells A2780 and Cal27 with IC50 of 1.48 μM and 1.47 μM, reverses Cisplatin (HY-17394) resistance in A2780 and Cal27 with IC50 of 4.62 μM and 2.23 μM. DS-103 exhibits synergistic effect with Cisplatin (HY-17394), enhances Cisplatin-induced apoptosis .
Cat. No.: HY-P991371
Synonyms: PF-06664178 antibody; RN926
Cat. No.: HY-16587A
CAS No.: 1169829-40-6
Synonyms: IPI 926 hydrochloride; Patidegib hydrochloride
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
Cat. No.: HY-RS02276
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CD8B Human Pre-designed siRNA Set A contains three designed siRNAs for CD8B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P86810
Synonyms: CD8b antigen antibody; CD_antigen=CD8b antibody; CD8 antigen 37 kDa chain antibody; CD8 antigen beta polypeptide 1 (p37) antibody; CD8 antigen beta polypeptide 1 antibody; CD8 antigen, beta chain antibody; CD8 antigen, beta polypeptide 1 (p37) antibody; CD8 antigen, beta polypeptide 1 antibody; CD8 beta antibody; CD8b antibody; CD8b antigen antibody; CD_antigen=CD8b antibody; CD8 antigen 37 kDa chain antibody; CD8 antigen beta polypeptide 1 (p37) antibody; CD8 antigen beta polypeptide 1 antibody; CD8 antigen, beta chain antibody; CD8 antigen, beta polypeptide 1 (p37) antibody; CD8 antigen, beta polypeptide 1 antibody; CD8 beta antibody; CD8b antibody; CD8b molecule antibody; CD8B_HUMAN antibody; CD8B1 antibody; Flags: Precursor antibody; Leu2 antibody; Ly3 antibody; LYT3 antibody; MGC119115 antibody; OTTHUMP00000160762 antibody; OTTHUMP00000160763 antibody; OX 8 membrane antigen antibody; P37 antibody; T cell surface glycoprotein CD8 antibody; T cell surface glycoprotein CD8 beta chain antibody; T lymphocyte surface glycoprotein beta chain antibody; T-cell surface glycoprotein CD8 beta chain antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
