2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. CAI/II-IN-12

CAI/II-IN-12 is a potent and hCAI (IC50 = 7.12 μM, Ki = 9.26 μM) and hCAII (IC50 = 10.62 μM, Ki = 11.72 μM) dual inhibitor. CAI/II-IN-12 has a strong affinity for the active sites of CYP17A1, hCAI, and hCAII enzymes. Compound CAI/II-IN-12 exhibits rapid conformational stabilization, particularly in the CYP17A1 complex. CAI/II-IN-12 can be used for the study of prostate cancer therapy and glaucoma.

For research use only. We do not sell to patients.

CAI/II-IN-12

CAI/II-IN-12 Chemical Structure

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CAI/II-IN-12 Related Antibodies

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Description

CAI/II-IN-12 is a potent and hCAI (IC50 = 7.12 μM, Ki = 9.26 μM) and hCAII (IC50 = 10.62 μM, Ki = 11.72 μM) dual inhibitor. CAI/II-IN-12 has a strong affinity for the active sites of CYP17A1, hCAI, and hCAII enzymes. Compound CAI/II-IN-12 exhibits rapid conformational stabilization, particularly in the CYP17A1 complex. CAI/II-IN-12 can be used for the study of prostate cancer therapy and glaucoma[1].

IC50 & Target

hCA I

7.12 μM (IC50)

hCA II

10.62 μM (IC50)

In Vitro

CAI/II-IN-12 (Compound 6d) (1-100 μM, 24 h) shows selective inhibitory activity against prostate cancer cells (DU145) and low toxicity against normal cells (PNT1a)[1].
CAI/II-IN-12 demonstrates significant potential to establish a coordination bond between the carbonyl oxygen of its triazole moiety and the central iron atom within the HEM group of the enzyme upon binding to CYP17A1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAI/II-IN-12 Related Antibodies

Cell Viability Assay[1]

Cell Line: DU145 cells, PNT1a cells
Concentration: 1 μM, 10 μM, 100 μM
Incubation Time: 24 h
Result: In DU145 cancer cells, exhibited dose-dependent inhibition of cell viability.
In normal PNT1a cells, the IC50 value was 113.44 μM, and the selectivity index (SI) was 2.28.
Molecular Weight

504.56

Formula

C26H24N4O5S
SMILES

O=S(C1=CC=C(C)C=C1)(OC2=CC=CC(/C=N/N3C(CC4=CC=C(C)C=C4)=NN(C(C)=O)C3=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAI/II-IN-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAI/II-IN-12Carbonic AnhydraseCarbonate dehydratase1,2,4-TriazolesProstate cancerCarbonic anhydrase inhibitorsCYP17A1Inhibitorinhibitorinhibit

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