CAI/II-IN-12
CAI/II-IN-12 is a potent and hCAI (IC50 = 7.12 μM, Ki = 9.26 μM) and hCAII (IC50 = 10.62 μM, Ki = 11.72 μM) dual inhibitor. CAI/II-IN-12 has a strong affinity for the active sites of CYP17A1, hCAI, and hCAII enzymes. Compound CAI/II-IN-12 exhibits rapid conformational stabilization, particularly in the CYP17A1 complex. CAI/II-IN-12 can be used for the study of prostate cancer therapy and glaucoma.
For research use only. We do not sell to patients.
- Formula: C26H24N4O5S
- Molecular Weight:504.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA I 7.12 μM (IC50) |
hCA II 10.62 μM (IC50) |
CAI/II-IN-12 (Compound 6d) (1-100 μM, 24 h) shows selective inhibitory activity against prostate cancer cells (DU145) and low toxicity against normal cells (PNT1a)[1].
CAI/II-IN-12 demonstrates significant potential to establish a coordination bond between the carbonyl oxygen of its triazole moiety and the central iron atom within the HEM group of the enzyme upon binding to CYP17A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DU145 cells, PNT1a cells
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Concentration:1 μM, 10 μM, 100 μM
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Incubation Time:24 h
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Result:In DU145 cancer cells, exhibited dose-dependent inhibition of cell viability.
In normal PNT1a cells, the IC50 value was 113.44 μM, and the selectivity index (SI) was 2.28.
Chemical Information
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Molecular Weight 504.56
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Formula C26H24N4O5S
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SMILES
O=S(C1=CC=C(C)C=C1)(OC2=CC=CC(/C=N/N3C(CC4=CC=C(C)C=C4)=NN(C(C)=O)C3=O)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAI/II-IN-12 Related Classifications
HY-175972 Related Classifications
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