Search Result

Results for "

ALS Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (27) Amylin Receptor (1) Amyloid-β (1) Autophagy (1) Bacterial (2) Bcr-Abl (3) DNA/RNA Synthesis (1) Drug Metabolite (1) E1/E2/E3 Enzyme (2) Endogenous Metabolite (1) Endothelin-Converting Enzyme (ECE) (1) Environmental Pollutants (7) Fungal (5) GSK-3 (1) Herbicide (17) HPPD (1) iGluR (2) Isotope-Labeled Compounds (4) JAK (1) JNK (3) MAP3K (1) MAP4K (2) Mitochondrial Metabolism (1) Mixed Lineage Kinase (1) Monoamine Oxidase (1) mTOR (1) nAChR (1) NEKs (1) p62 (2) Parasite (1) Reactive Oxygen Species (ROS) (2) Reference Standards (10) ROCK (1) RSV (2) SOD (6) Tau Protein (1) Toll-like Receptor (TLR) (2) TRP Channel (2) α-synuclein (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (9) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (24)

By Targets:

Acetolactate Synthase (ALS) (27)

Amylin Receptor (1)

Amyloid-β (1)

Autophagy (1)

Bacterial (2)

Bcr-Abl (3)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

E1/E2/E3 Enzyme (2)

Endogenous Metabolite (1)

Endothelin-Converting Enzyme (ECE) (1)

Environmental Pollutants (7)

Fungal (5)

GSK-3 (1)

Herbicide (17)

HPPD (1)

iGluR (2)

Isotope-Labeled Compounds (4)

JAK (1)

JNK (3)

MAP3K (1)

MAP4K (2)

Mitochondrial Metabolism (1)

Mixed Lineage Kinase (1)

Monoamine Oxidase (1)

mTOR (1)

nAChR (1)

NEKs (1)

p62 (2)

Parasite (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (10)

ROCK (1)

RSV (2)

SOD (6)

Tau Protein (1)

Toll-like Receptor (TLR) (2)

TRP Channel (2)

α-synuclein (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Infection (9)

Inflammation/Immunology (3)

Metabolic Disease (3)

Neurological Disease (24)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Acetolactate Synthase (ALS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14774

Monepantel 1 Publications Verification AAD1566; NUZ-001	mTOR Parasite nAChR Autophagy	Infection Neurological Disease Cancer
Monepantel (AAD1566, NUZ-001), an antiparasitic agent, is an orally active mTOR inhibitor. Monepantel triggers autophagy through the deactivation of mTOR/p70S6K signalling pathway. Monepantel is a positive allosteric modulator of a nematode-specific clade of nAChR subunits. Monepantel can be used for the study of amyotrophic lateral sclerosis (ALS) and ovarian cancer .

HY-114332

GNE-8505	MAP3K JNK	Neurological Disease Metabolic Disease
GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 has an IC₅₀ of 0.144 μM for pJNK, and EC₅₀ of 0.457 μM for DRG. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS) .

HY-B1876

Nicosulfuron	Environmental Pollutants Acetolactate Synthase (ALS)	Others
Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits *acetolactate synthase (ALS)* enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs), which is proming for maize cultivation .

HY-12983

ALS-8112 3 Publications Verification	RSV	Infection
ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC₅₀ of 0.02 μM.

HY-B1847

Terbuthylazine 1 Publications Verification	Environmental Pollutants Acetolactate Synthase (ALS) Herbicide	Others
Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein .

HY-100427

Imazamox CL29926; (±)-Imazamox	Environmental Pollutants Acetolactate Synthase (ALS)	Others
Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .

HY-144425

BSc5367	NEKs	Inflammation/Immunology
BSc5367 is a potent Nek1 inhibitor with an IC₅₀ of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer .

HY-B0869A

Bispyribac sodium	Environmental Pollutants SOD Acetolactate Synthase (ALS) Herbicide	Metabolic Disease
Bispyribac sodium is a selective, orally active, systemic and post-emergence herbicide. Bispyribac sodium reduces SOD levels and inhibits *ALS* activity. Bispyribac sodium blocks the biosynthesis of branched-chain amino acids, resulting in growth retardation, chlorosis and necrosis of weeds. Bispyribac sodium exerts herbicidal activity against grass, sedge and broadleaf weeds in rice fields. Bispyribac sodium is hepatotoxic and genotoxic .

HY-W040206

Diflufenican	Environmental Pollutants Acetolactate Synthase (ALS) Herbicide	Others
Diflufenican is a Herbicide. Diflufenican inhibits phytoene desaturase (PDS) in the carotenoid synthesis pathway. Diflufenican suppresses the production of PDS, blocks carotenoid biosynthesis, thereby inducing chlorophyll destruction and cell membrane rupture, and ultimately causes the death of broadleaf weeds. The combination of Diflufenican and Flufenacet can be used to control Lolium rigidum populations resistant to ALS/ACCase .

HY-168972

Famlasertib Prostetin/12k	MAP4K Mixed Lineage Kinase	Neurological Disease Inflammation/Immunology
Famlasertib is a potent, brain-penetrant MAP4K inhibitor with IC₅₀s value of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively. Famlasertib shows motor neuron protection and anti-inflammatory properties. Famlasertib can be used for the study of amyotrophic lateral sclerosis (ALS) .

HY-12983A

Lumicitabine 1 Publications Verification ALS-008176; ALS-8176	RSV	Infection
Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.

HY-125999

EPI-589	Reactive Oxygen Species (ROS)	Neurological Disease
EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .

HY-126987

Mesosulfuron-methyl	Environmental Pollutants Acetolactate Synthase (ALS)	Others
Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .

HY-148629

GDC-0134	JNK	Neurological Disease
GDC-0134 (RG6000) is a modulator targeting dual leucine zipper kinase (DLK) that can cross the blood-brain barrier. By inhibiting the kinase activity of DLK, GDC-0134 blocks the activation of the downstream JNK signaling pathway, suppresses DLK-dependent retrograde signal transduction of axon-to-soma degeneration, and exerts neuroprotective activity. GDC-0134 reduces TDP-43 protein aggregation and decreases the degree of neuromuscular junction denervation in motor neurons. GDC-0134 can be used in the research of amyotrophic lateral sclerosis (ALS), Alzheimer's disease and other DLK-related neurodegenerative diseases .

HY-W611371

FP802	TRP Channel iGluR	Neurological Disease
FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS). FP802 can be used for AD and ALS research .

HY-B1852

Sulfometuron-methyl	Bacterial Fungal	Infection
Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III .

HY-153019

NUCC-0000323	SOD	Neurological Disease
NUCC-0000323 is a potent superoxide dismutase 1 (SOD1) inhibitor. NUCC-0000323 inhibits SOD1 expression. NUCC-0000323 can be used in research of amyotrophic lateral sclerosis (ALS) .

HY-172967

SARM1-IN-5	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) .

HY-123982

*SOD1-Derlin-1 inhibitor-2*	SOD	Neurological Disease
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1 ^mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS) .

HY-B1876S

Nicosulfuron-d6	Acetolactate Synthase (ALS)	Others
Nicosulfuron-d₆ is the deuterium labeled Nicosulfuron . Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .

HY-100427R

Imazamox (Standard) CL29926 (Standard); (±)-Imazamox (Standard)	Reference Standards Acetolactate Synthase (ALS)	Others
Imazamox (Standard) is the analytical standard of Imazamox. This product is intended for research and analytical applications. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .

HY-178732

AB-22	Fungal Acetolactate Synthase (ALS) Endothelin-Converting Enzyme (ECE)	Infection
AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of *ALS3, HWP1, and ECE1* in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis .

HY-P3709

TRAF6 peptide	p62 E1/E2/E3 Enzyme	Neurological Disease
TRAF6 peptide is a specific TRAF6-p62 inhibitor. TRAF6 peptide potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke .

HY-W611371A

FP802 dihydrochloride	TRP Channel iGluR	Neurological Disease
FP802 dihydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 dihydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 dihydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) . FP802 dihydrochloride can be used for AD and ALS research .

HY-B1845

Florasulam	Environmental Pollutants Herbicide	Others
Florasulam is a targeted post-emergent herbicide belonging to the triazolopyrimidine sulfonanilide class, which functions by inhibiting acetolactate synthase (ALS) in plants. Located in the chloroplasts, ALS plays a crucial role in the biosynthesis of branched-chain amino acids. When Florasulam inhibits ALS, it disrupts plant cell division, reduces growth, and ultimately leads to plant death.

HY-121727

Triafamone AE 1887196; BCS-BX60309	Acetolactate Synthase (ALS)	Others
Triafamone (AE 1887196) is a paddy field pre-emergence and post-emergence sulfonamide herbicide. Triafamone weeds by inhibiting the acetolactate synthase (ALS) enzyme, thereby blocking the biosynthesis of branched-chain amino acids .

HY-W422402

Foramsulfuron	Acetolactate Synthase (ALS) Herbicide	Others
Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .

HY-B1876R

Nicosulfuron (Standard)	Reference Standards Acetolactate Synthase (ALS)	Others
Nicosulfuron (Standard) is the analytical standard of Nicosulfuron. This product is intended for research and analytical applications. Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .

HY-P3709A

TRAF6 peptide TFA	p62 E1/E2/E3 Enzyme	Neurological Disease
TRAF6 peptide TFA is a specific TRAF6-p62 inhibitor. TRAF6 peptide TFA potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide TFA has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke .

HY-114898

ML404	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease
ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC₅₀=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke .

HY-179533

SOD1-aggregation-IN-1	SOD	Neurological Disease
SOD1-aggregation-IN-1 (compound 20) is a potent SOD aggregation inhibitor. SOD1-aggregation-IN-1 inhibits MG132 (HY-13259)-induced mutant SOD1 intracellular aggregation in PC12-SOD1 ^G85R YFP cells with an EC₅₀ of 2.63 μM. SOD1-aggregation-IN-1 can be used for amyotrophic lateral sclerosis (ALS) research .

HY-146527

c-ABL-IN-2	Bcr-Abl	Neurological Disease Cancer
c-ABL-IN-2 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-2 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2020260871A1, compound 25) . c-ABL-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1852R

Sulfometuron-methyl (Standard)	Bacterial Reference Standards Fungal	Infection
Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III .

HY-B1845R

Florasulam (Standard)	Endogenous Metabolite Reference Standards	Others
Florasulam (Standard) is the analytical standard of Florasulam. This product is intended for research and analytical applications. Florasulam is a targeted post-emergent herbicide belonging to the triazolopyrimidine sulfonanilide class, which functions by inhibiting acetolactate synthase (ALS) in plants. Located in the chloroplasts, ALS plays a crucial role in the biosynthesis of branched-chain amino acids. When Florasulam inhibits ALS, it disrupts plant cell division, reduces growth, and ultimately leads to plant death.

HY-W662572

Pyroxsulam	Acetolactate Synthase (ALS)	Others
Pyroxsulam is a selective, foliar-applied acetolactate synthase (ALS)-inhibiting herbicide. Pyroxsulam can be used for the study of grassy weed management in winter wheat systems .

HY-112785

Pyriftalid	Herbicide Acetolactate Synthase (ALS)	Others
Pyriftalid is one of the most commonly used herbicides that inhibits the synthesis of acetyl lactate synthase (ALS). Pyriftalid is mainly used to prevent poaceae weeds and some broadleaf weeds in paddy fields .

HY-B1847S1

Terbuthylazine-d5	Isotope-Labeled Compounds Herbicide Acetolactate Synthase (ALS)	Others
Terbuthylazine-d₅ is the deuterium labeled Terbuthylazine (HY-B1847) . Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein.

HY-162303

C175-0062	Monoamine Oxidase	Neurological Disease
C175-0062 is a monoamine oxidase B (MAO-B) inhibitor. C175-0062 can be used for the research of neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS) .

HY-126987R

Mesosulfuron-methyl (Standard)	Acetolactate Synthase (ALS) Reference Standards	Others
Mesosulfuron-methyl (Standard) is the analytical standard of Mesosulfuron-methyl. This product is intended for research and analytical applications. Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .

HY-B1847R

Terbuthylazine (Standard)	Reference Standards Herbicide Acetolactate Synthase (ALS)	Others
Terbuthylazine (Standard) is the analytical standard of Terbuthylazine (HY-B1847). This product is intended for research and analytical applications. Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein.

HY-100427S

Imazamox-13C,d3 CL29926-¹³C,d₃; (±)-Imazamox-¹³C,d₃	Acetolactate Synthase (ALS) Isotope-Labeled Compounds	Others
Imazamox- ¹³C,d₃ is the ¹³C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .

HY-168269

Tyk2-IN-20	JAK	Cancer
Tyk2-IN-20 (Example 289) is a potent Tyk2 inhibitor with an IC₅₀ of <5 nM. Tyk2-IN-20 als inhibits JAK1, JAK2, and JAK3 with IIC₅₀ values of <100 nM. Tyk2-IN-20 can be used for the study of inflammatory diseases .

HY-N2707

6-Deoxyjacareubin	Reactive Oxygen Species (ROS)	Neurological Disease Cancer
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS) .

HY-112785R

Pyriftalid (Standard)	Reference Standards Herbicide Acetolactate Synthase (ALS)	Others
Pyriftalid (Standard) is the analytical standard of Pyriftalid (HY-112785). This product is intended for research and analytical applications. Pyriftalid is one of the most commonly used herbicides that inhibits the synthesis of acetyl lactate synthase (ALS). Pyriftalid is mainly used to prevent poaceae weeds and some broadleaf weeds in paddy fields .

HY-114270

JGK-263	GSK-3	Neurological Disease
JGK-263 is an orally active Glycogen synthase kinase-3β (GSK-3β) inhibitor. JGK-263 exhibits neuroprotective effect and can improve motor function. JGK-263 can be used for the research of neurological disease, such as amyotrophic lateral sclerosis (ALS) .

HY-W422402R

Foramsulfuron (Standard)	Reference Standards Acetolactate Synthase (ALS)	Others
Foramsulfuron (Standard) is the analytical standard of Foramsulfuron. This product is intended for research and analytical applications. Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .

HY-146528

c-ABL-IN-3	Bcr-Abl	Neurological Disease Cancer
c-ABL-IN-3 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-3 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2021048567A1, compound 50) .

HY-W721637

Foramsulfuron-d6-1	Isotope-Labeled Compounds Acetolactate Synthase (ALS)	Others
Foramsulfuron-d₆-1 is the deuterium labeled Foramsulfuron (HY-W422402). Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .

HY-146530

c-ABL-IN-4	Bcr-Abl	Neurological Disease Cancer
c-ABL-IN-4 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-4 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2021048567A1, compound 54) .

HY-145294

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

1,063 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 1,063 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Target	Research Area