54947-74-9
Chemical Structure
4-Methyloctanoic acid
- CAS No.: 54947-74-9
- Formula:C9H18O2
- Molecular Weight:158.24
IUPAC Name: 4-methyloctanoic acid
InChIKey: LEGGANXCVQPIAI-UHFFFAOYSA-N
SMILES: CCCCC(C)CCC(O)=O
Biological Activity: 4-Methyloctanoic acid is an endogenous branched-chain medium-chain fatty acid and a negative regulator of the cAMP/PKA signaling pathway. 4-Methyloctanoic acid exerts antiepileptic effects by inhibiting epileptiform discharges and terminating behavioral and electroencephalographic seizures. 4-Methyloctanoic acid has neuroprotective effects; its polar metabolites can cross the blood-brain barrier, repair presynaptic release defects, improve motor function and alleviate neuromuscular degeneration in ALS models. 4-Methyloctanoic acid regulates phosphatidylinositol metabolism, reduces PIP/PIP2 levels and increases inositol levels. 4-Methyloctanoic acid can be used in studies related to epilepsy and amyotrophic lateral sclerosis[1][2][3][4][5][6][7].
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4-Methyloctanoic acid | 99.85% | 4-Methyloctanoic acid is an endogenous branched-chain medium-chain fatty acid and a negative regulator of the cAMP/PKA signaling pathway. 4-Methyloctanoic acid exerts antiepileptic effects by inhibiting epileptiform discharges and terminating behavioral and electroencephalographic seizures. 4-Methyloctanoic acid has neuroprotective effects; its polar metabolites can cross the blood-brain barrier, repair presynaptic release defects, improve motor function and alleviate neuromuscular degeneration in ALS models. 4-Methyloctanoic acid regulates phosphatidylinositol metabolism, reduces PIP/PIP2 levels and increases inositol levels. 4-Methyloctanoic acid can be used in studies related to epilepsy and amyotrophic lateral sclerosis. | ||||||||||||||||||||
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4-Methyloctanoic acid (Standard) | ≥98% | 4-Methyloctanoic acid (Standard) is the analytical standard of 4-Methyloctanoic acid (HY-W010178). This product is intended for research and analytical applications. 4-Methyloctanoic acid is an endogenous branched-chain medium-chain fatty acid and a negative regulator of the cAMP/PKA signaling pathway. 4-Methyloctanoic acid exerts antiepileptic effects by inhibiting epileptiform discharges and terminating behavioral and electroencephalographic seizures. 4-Methyloctanoic acid has neuroprotective effects; its polar metabolites can cross the blood-brain barrier, repair presynaptic release defects, improve motor function and alleviate neuromuscular degeneration in ALS models. 4-Methyloctanoic acid regulates phosphatidylinositol metabolism, reduces PIP/PIP2 levels and increases inositol levels. 4-Methyloctanoic acid can be used in studies related to epilepsy and amyotrophic lateral sclerosis. | ||||||||||||||||||||
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References
- [1]. Chang PS. Valproate and 4-methyloctanoic acid, an analogue of valproate, in animal models of epilepsy (Doctoral dissertation, UCL (University College London)).
- [2]. Chang P, et al. Seizure control by ketogenic diet-associated medium chain fatty acids. Neuropharmacology. 2013;69:105-114. [Content Brief]
- [3]. Walker MC, et al. New experimental therapies for status epilepticus in preclinical development. Epilepsy & Behavior. 2015 Aug 1;49:290-3. [Content Brief]
- [4]. Nagatsugi F, et al. 18F-labeled octanoates as potential agents for cerebral fatty acid studies. The influence of 4-substitution and the fluorine position on biodistribution. Chem Pharm Bull (Tokyo). 1995 Apr;43(4):607-15. [Content Brief]
- [5]. Dunn E, et al. Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral Sclerosis. Cells. 2023;12(17):2163. Published 2023 Aug 28. [Content Brief]
- [6]. Chang P, et al. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis Model Mech. 2012;5(1):115-124. [Content Brief]
