4-Methyloctanoic acid-d4
4-Methyloctanoic acid-d4 is the deuterated-labeled 4-Methyloctanoic acid (HY-W010178). 4-Methyloctanoic acid is an endogenous branched-chain medium-chain fatty acid and a negative regulator of the cAMP/PKA signaling pathway. 4-Methyloctanoic acid exerts antiepileptic effects by inhibiting epileptiform discharges and terminating behavioral and electroencephalographic seizures. 4-Methyloctanoic acid has neuroprotective effects; its polar metabolites can cross the blood-brain barrier, repair presynaptic release defects, improve motor function and alleviate neuromuscular degeneration in ALS models. 4-Methyloctanoic acid regulates phosphatidylinositol metabolism, reduces PIP/PIP2 levels and increases inositol levels. 4-Methyloctanoic acid can be used in studies related to epilepsy and amyotrophic lateral sclerosis.
For research use only. We do not sell to patients.
- Formula: C9H14D4O2
- Molecular Weight:162.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 54947-74-9
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Molecular Weight 162.26
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Formula C9H14D4O2
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SMILES
CCCCC(C([2H])([2H])C([2H])([2H])C(O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Chang P, et al. Seizure control by ketogenic diet-associated medium chain fatty acids. Neuropharmacology. 2013;69:105-114. [Content Brief]
[3]. Walker MC, et al. New experimental therapies for status epilepticus in preclinical development. Epilepsy & Behavior. 2015 Aug 1;49:290-3. [Content Brief]
[4]. Nagatsugi F, et al. 18F-labeled octanoates as potential agents for cerebral fatty acid studies. The influence of 4-substitution and the fluorine position on biodistribution. Chem Pharm Bull (Tokyo). 1995 Apr;43(4):607-15. [Content Brief]
[5]. Dunn E, et al. Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral Sclerosis. Cells. 2023;12(17):2163. Published 2023 Aug 28. [Content Brief]
[6]. Chang P, et al. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis Model Mech. 2012;5(1):115-124. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Methyloctanoic acid-d4 Related Classifications
HY-W010178S1 Related Classifications
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Keywords
- 4-Methyloctanoic acid-d4
- Isotope-Labeled Compounds
- Endogenous Metabolite
- PKA
- Protein kinase A
- seizure activity
- phosphatidylinositol bisphosphate
- cAMP/protein kinase A pathway
- epileptiform activity
- epilepsy
- mossy fibre
- phosphatidylinositol monophosphate
- amyotrophic lateral sclerosis
- blood-brain barrier
- inositol
- Inhibitor
- inhibitor
- inhibit