30 Results for "

Ang-1

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "Ang-1" in MCE Product Catalog:

  • Recombinant Proteins Recommended:
19
A 779
A 779
0 Images
19 Publications Verification
Cat. No.: HY-P0216
CAS No.: 159432-28-7
Target:  

Angiotensin Receptor

연구분야:  

Cardiovascular Disease Endocrinology

A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.
17
Talfirastide
Talfirastide
0 Images
17 Cited Publications
Cat. No.: HY-12403
CAS No.: 51833-78-4
Purity:  99.75%
Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7)
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1] .
17
Talfirastide acetate
Talfirastide acetate
0 Images
17 Cited Publications
Cat. No.: HY-12403A
CAS No.: 2855063-75-9
Purity:  99.87%
Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium [1] .
15
AVE 0991 sodium salt
AVE 0991 sodium salt
0 Images
15 Cited Publications
Cat. No.: HY-15778A
CAS No.: 306288-04-0
Purity:  99.22%
Target:  

Angiotensin Receptor

연구분야:  

Cardiovascular Disease Endocrinology

AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [ 125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM [1].
4
Razuprotafib
Razuprotafib
0 Images
4 Cited Publications
Cat. No.: HY-109041
CAS No.: 1008510-37-9
Purity:  ≥98.0%
Synonyms: AKB-9778
Target:  

Phosphatase Tie

연구분야:  

Inflammation/Immunology

Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) [1].
4
Flavokawain C
Flavokawain C
0 Images
4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
Category:  

Piperaceae Plants other families Flavonoids Chalcones Piper methysticum G.Forst. Phenols Polyphenols Disease Research Fields Cancer

Target:  

Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK

Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer [1] .
2
Angiopoietin-1 Protein, Human (HEK293, Fc)
Angiopoietin-1 Protein, Human (HEK293, Fc)
0 Images
2 Cited Publications
Cat. No.: HY-P70061
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuAngiopoietin-1/Ang1, Fc; AGP1; AGPT; Ang1; Ang-1; Angiopoietin 1; Angiopoietin-1; AngPT1
Species:  
Human
Source:  
HEK293
1
Angiopoietin-1 Protein, Mouse (HEK293, His)
Angiopoietin-1 Protein, Mouse (HEK293, His)
0 Images
1 Cited Publications
Cat. No.: HY-P74412A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1
Species:  
Mouse
Source:  
HEK293
Nesvacumab
Nesvacumab
0 Images
Cat. No.: HY-P99036
CAS No.: 1296818-77-3

Target:  

Tie

연구분야:  

Cardiovascular Disease Inflammation/Immunology Cancer

Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches [1] .
Trebananib
Trebananib
0 Images
Cat. No.: HY-P99546
CAS No.: 894356-79-7
Synonyms: 2xCon4C; AMG 386

Target:  

Tie

연구분야:  

Cardiovascular Disease Cancer

Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the TIE2 receptor. Trebananib has anti-angiogenic and anti-tumor activities [1] .
Zifibancimig
Zifibancimig
0 Images
Cat. No.: HY-P990689
CAS No.: 2517939-46-5
Synonyms: RO-7250284

Target:  

VEGFR

연구분야:  

Neurological Disease

Zifibancimig (RO-7250284) is a monoclonal antibody against VEGF-A and Ang-2, with affinities of 4 pM and 2 pM, respectively. Zifibancimig has high stability, maintains target-binding capability under physiological stress and storage conditions, and is designed for sustained long-term ocular delivery via the Port Delivery implant device. Zifibancimig can be used in the research of retinal diseases [1].
Diminazene
Diminazene
0 Images
Cat. No.: HY-W342283
CAS No.: 536-71-0
Target:  

Parasite Angiotensin-converting Enzyme (ACE) Angiotensin Receptor p38 MAPK STAT NF-κB TNF Receptor 5-HT Receptor

연구분야:  

Cardiovascular Disease Infection Inflammation/Immunology

Diminazene is an antiparasitic agent widely used to treat parasitic diseases caused by hemoparasites (such as trypanosomes and babesia). Diminazene acts as an ACE2 activator and exerts cardiovascular protective effects by activating the ACE2/Ang-(1-7)/Mas receptor axis. By regulating gut microbiota-tryptophan metabolism, Diminazene inhibits the activation of core inflammatory signaling pathways including MAPK, STAT and NF-κB, increases central 5-HT levels, and suppresses splenic TNF-α production, thereby alleviating systemic inflammation [1] .
AMG-780
AMG-780
0 Images
Cat. No.: HY-P991663

Target:  

Tie

연구분야:  

Cancer

AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC50 = 4.5 nM) and angiopoietin 2 (Ang2) (IC50 = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and Ang2. AMG-780 is indicated for the research of cancers such as colon cancer [1] .
ANGPT1/Angiopoietin-1, Rat (P. pastoris, His)
ANGPT1/Angiopoietin-1, Rat (P. pastoris, His)
0 Images
Cat. No.: HY-P700560
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Angiopoietin 1; Angiopoietin-1; Ang1; KIAA0003; Ang-1; AGP1; AGPT; Ang1
Species:  
Rat
Source:  
P. pastoris
Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc)
Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc)
0 Images
Cat. No.: HY-P76145
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1
Species:  
Cynomolgus
Source:  
HEK293
Angiopoietin-1 Protein, Cynomolgus (HEK293, His)
Angiopoietin-1 Protein, Cynomolgus (HEK293, His)
0 Images
Cat. No.: HY-P76146
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1
Species:  
Cynomolgus
Source:  
HEK293
Angiopoietin-1 Protein, Mouse (HEK293, His, solution)
Angiopoietin-1 Protein, Mouse (HEK293, His, solution)
0 Images
Cat. No.: HY-P74412
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGP1; AGPT; Ang-1; Angiopoietin-1; AngPT1
Species:  
Mouse
Source:  
HEK293
Talfirastide (Standard)
Talfirastide (Standard)
0 Images
Cat. No.: HY-12403R
CAS No.: 51833-78-4
Synonyms: TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Reference Standards

Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1] .
TM7SF2 Human Pre-designed siRNA Set A
TM7SF2 Human Pre-designed siRNA Set A
Cat. No.: HY-RS14612
Target:  

Small Interfering RNA (siRNA)

연구분야:  

Others

TM7SF2 Human Pre-designed siRNA Set A contains three designed siRNAs for TM7SF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ANGPT1 Human Pre-designed siRNA Set A
ANGPT1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS00687
Target:  

Small Interfering RNA (siRNA)

연구분야:  

Others

ANGPT1 Human Pre-designed siRNA Set A contains three designed siRNAs for ANGPT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Assay Types