Talfirastide (Standard)
Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 95%
- CAS. Nr.: 51833-78-4
- Formel: C41H62N12O11
- Molecular Weight:899.00
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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HY-12403
TalfirastideVasodilator Agent -
HY-13948A
Angiotensin II human acetateVasoconstrictor -
HY-13948
Angiotensin II humanVasoconstrictor -
HY-P1540
Angiotensin III, human, mouseAT2R Agonist -
HY-B0368
CaptoprilACE Inhibitor -
HY-18204
ValsartanAngiotensin II Receptor Antagonist -
HY-B0202
IrbesartanAT1 Receptor Blocker -
HY-17512
LosartanAngiotensin II Receptor Antagonist -
HY-18204A
Sacubitril/ValsartanARN Inhibitor -
HY-P1032
Angiotensin I (human, mouse, rat)Decapeptide Hormone -
HY-13955
TelmisartanAngiotensin II Type 1 Receptor -
HY-B0279
RamiprilApoptosis Inducer
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 51833-78-4
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Molecular Weight 899.00
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Formel C41H62N12O11
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SMILES
O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@@]([C@@H](C)CC)([H])NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC=N3
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Synonyms
TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Gómez-Mendoza DP, et al. Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486. [Content Brief]
[2]. Li P, et al. Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29(1 Pt 2):394-400. [Content Brief]
[3]. Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11(3):e0150861. [Content Brief]
[4]. Alzayadneh EM, et al. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568(14)00314-3. [Content Brief]
[5]. Janatpour ZC, et al. Subcutaneous Administration of Angiotensin-(1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36(22):3115-3131. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Talfirastide (Standard) Related Classifications
HY-12403R Related Classifications
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