536-71-0
Chemical Structure
Diminazene
- CAS No.: 536-71-0
- Formula:C14H15N7
- Molecular Weight:281.32
IUPAC Name: 6-methoxynaphthalen-1-amine
InChIKey: XNYZHCFCZNMTFY-UHFFFAOYSA-N
SMILES: N=C(C1=CC=C(C=C1)/N=N/NC2=CC=C(C(N)=N)C=C2)N
Biological Activity: Diminazene is an antiparasitic agent widely used to treat parasitic diseases caused by hemoparasites (such as trypanosomes and babesia). Diminazene acts as an ACE2 activator and exerts cardiovascular protective effects by activating the ACE2/Ang-(1-7)/Mas receptor axis. By regulating gut microbiota-tryptophan metabolism, Diminazene inhibits the activation of core inflammatory signaling pathways including MAPK, STAT and NF-κB, increases central 5-HT levels, and suppresses splenic TNF-α production, thereby alleviating systemic inflammation[1][2][3][4][5][6].
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Diminazene | Diminazene is an antiparasitic agent widely used to treat parasitic diseases caused by hemoparasites (such as trypanosomes and babesia). Diminazene acts as an ACE2 activator and exerts cardiovascular protective effects by activating the ACE2/Ang-(1-7)/Mas receptor axis. By regulating gut microbiota-tryptophan metabolism, Diminazene inhibits the activation of core inflammatory signaling pathways including MAPK, STAT and NF-κB, increases central 5-HT levels, and suppresses splenic TNF-α production, thereby alleviating systemic inflammation. | |||||||||||||||||||||
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- [1]. Qaradakhi T, et al. The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases. Clin Exp Pharmacol Physiol. 2020;47(5):751-758. [Content Brief]
- [2]. Joviano-Santos JV, et al. Diminazene aceturate (DIZE) has cellular and in vivo antiarrhythmic effects. Clin Exp Pharmacol Physiol. 2020;47(2):213-219. [Content Brief]
- [3]. Lu Z, et al. Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model. BMC Pharmacol Toxicol. 2022;23(1):44. Published 2022 Jul 4. [Content Brief]
- [4]. Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound?. Int Immunopharmacol. 2014;21(2):342-345. [Content Brief]
- [5]. Passaglia P, et al. Diminazene aceturate attenuates systemic inflammation via microbiota gut-5-HT brain-spleen sympathetic axis in male mice. Brain Behav Immun. 2024;119:105-119. [Content Brief]
- [6]. de Brito MG, et al. Therapeutic Effect of Diminazene Aceturate on Parasitic Blood Fluke Schistosoma mansoni Infection. Antimicrob Agents Chemother. 2020;64(11):e01372-20. Published 2020 Oct 20. [Content Brief]
Keywords
