82 Results for "

Arg-Arg-Arg-Arg

" in MedChemExpress (MCE) Product Catalog:
Products (82)

82 Results for "Arg-Arg-Arg-Arg" in MCE Product Catalog:

7
Hexa-D-arginine
Hexa-D-arginine
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7 Publications Verification
Referencia número: HY-P1028
No. CAS: 673202-67-0
Synonyms: Furin Inhibitor II
Target:  

Bacterial

Áreas de investigación:  

Infection

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
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7
Hexa-D-arginine TFA
Hexa-D-arginine TFA
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7 Publications Verification
Referencia número: HY-P1028A
No. CAS: 958204-56-3
Synonyms: Furin Inhibitor II TFA
Target:  

Bacterial

Áreas de investigación:  

Infection

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
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2
GO-203 TFA
GO-203 TFA
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2 Cited Publications
Referencia número: HY-P1925A
No. CAS: 1222186-26-6
Target:  

PI3K Reactive Oxygen Species (ROS) Apoptosis

Áreas de investigación:  

Cancer

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .
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2
ReACp53
ReACp53
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2 Cited Publications
Referencia número: HY-P0121
Target:  

MDM-2/p53

Áreas de investigación:  

Cancer

ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.
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1
(Arg)9 TFA
(Arg)9 TFA
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1 Cited Publications
Referencia número: HY-P0133A
No. CAS: 2283335-13-5
Synonyms: Nona-L-Arginine TFA; Peptide R9 TFA
Target:  

Ser/Thr Protease

Áreas de investigación:  

Neurological Disease

(Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model .
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1
RSM3
RSM3
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1 Cited Publications
Referencia número: HY-P10387
Target:  

METTL3 Apoptosis MDM-2/p53 NF-κB Caspase

Áreas de investigación:  

Cancer

RSM3 is a METTL3-METTL14 complex inhibitor with a Kd of 3.10 μM for the METTL3-METTL14 complex. RSM3 reduces the m 6A modification level of SLC31A1 and the global RNA methylation level. RSM3 upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 is applicable to the research of preeclampsia and cancer .
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1
APTSTAT3-9R
APTSTAT3-9R
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1 Cited Publications
Referencia número: HY-P2282
Target:  

STAT

Áreas de investigación:  

Cancer

APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .
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1
RSM3 TFA
RSM3 TFA
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1 Cited Publications
Referencia número: HY-P10387A
Target:  

METTL3 Apoptosis

Áreas de investigación:  

Cancer

RSM3 TFA is a METTL3-METTL14 complex inhibitor with a Kd of 3.10 μM for the METTL3-METTL14 complex. RSM3 TFA reduces the m 6A modification level of SLC31A1 and the global RNA methylation level. RSM3 TFA upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 TFA is applicable to the research of preeclampsia and cancer .
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Tat-NTS peptide
Tat-NTS peptide
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Referencia número: HY-P10275
Target:  

Apoptosis

Áreas de investigación:  

Neurological Disease

Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke .
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(Arg) 9
(Arg) 9
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Referencia número: HY-P0133
No. CAS: 143413-47-2
Synonyms: Nona-L-Arginine; Peptide R9
Target:  

Ser/Thr Protease

Áreas de investigación:  

Neurological Disease

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model .
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FPP29
FPP29
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Referencia número: HY-P11228
Target:  

PROTACs FOXM1 Apoptosis DNA/RNA Synthesis

Áreas de investigación:  

Cancer

FPP29 is a potent peptide-based FOXM1 PROTAC degrader. FPP29 induces ubiquitination and degradation of FOXM1. FPP29 inhibits FOXM1 via the ubiquitin-proteasome degradation pathway. FPP29 induces Apoptosis. FPP29 suppresses tumor growth in hepatocellular carcinoma xenograft models. FPP29 can be used in the research of hepatocellular carcinoma (cell-penetrating peptide: (HY-P0133); VHL ligase ligand: (HY-P11493); linker: (HY-W013664); FOXM1 ligand: (HY-P11494)) .
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Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)
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Referencia número: HY-P4086
No. CAS: 1678417-57-6
Target:  

RABV nAChR

Áreas de investigación:  

Neurological Disease Cancer

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is a cell-penetrating peptide that is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) binds to
nAChR on neuronal cells to mediate receptor-mediated endocytosis and targeted siRNA delivery. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) protects complexed siRNA from degradation, enhances transcellular siRNA delivery in neuronal cells, and promotes efficient, pecific gene silencing. Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) can be used for the researches of neurological disease and cancer .
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NP213 TFA
NP213 TFA
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Referencia número: HY-126810A
Pureza:  99.80%
Target:  

Fungal

Áreas de investigación:  

Infection

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
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TP4 (Nile tilapia piscidin)
TP4 (Nile tilapia piscidin)
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Referencia número: HY-P5557
No. CAS: 1429184-62-2
Target:  

Bacterial Necroptosis

Áreas de investigación:  

Infection Inflammation/Immunology

TP4 (Nile tilapia piscidin) is an orally active amphipathic α-helical cationic antimicrobial peptide. TP4 (Nile tilapia piscidin) exerts broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria by disrupting cell membrane structures, and also exhibits certain hemolytic activity. TP4 (Nile tilapia piscidin) regulates the innate immune system and enhances the expression of lysozymes, cytokines and antioxidant enzymes to resist bacterial infection. TP4 (Nile tilapia piscidin) also stimulates the proliferation of keratinocytes and fibroblasts, and significantly promotes the healing of wounds infected with MRSA. TP4 (Nile tilapia piscidin) can be used in research related to bacterial infection, peritonitis, wound healing and other fields .
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Arg-Arg-Arg-Arg acetate
Arg-Arg-Arg-Arg acetate
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Referencia número: HY-P4250A
Target:  

Biochemical Assay Reagents

Áreas de investigación:  

Others

Arg-Arg-Arg-Arg (acetate), consisting of four arginines, is used in cell-penetrating peptide-based gene delivery vehicles .
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TAT-PiET-PROTAC
TAT-PiET-PROTAC
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Referencia número: HY-P10446
No. CAS: 3036046-04-2
Target:  

Epigenetic Reader Domain PROTACs

Áreas de investigación:  

Cancer

TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445), which is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can reduce BRD4 and JMJD6 levels and inhibit cell proliferation. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells. TAT-PiET-PROTAC can be used for the research of cancer, such as breast cancer .
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Cys(NPys)-D{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg}-NH2
Cys(NPys)-D{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg}-NH2
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Referencia número: HY-P4316
No. CAS: 1676104-79-2
Target:  

Peptides

Áreas de investigación:  

Others

Cys(NPys)-D{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg}-NH2 is a cell-penetrating polypeptide composed of nine arginines and cysteines, used to carry therapeutic agent into the cell .
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Arg-Arg-Arg-Arg
Arg-Arg-Arg-Arg
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Referencia número: HY-P4250
No. CAS: 26791-46-8
Target:  

Peptides

Áreas de investigación:  

Others

Tetraarginine (RRRR), consisting of four arginines, is used in cell-penetrating peptide-based gene delivery vehicles .
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(Arg)9, FAM-labeled
(Arg)9, FAM-labeled
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Referencia número: HY-P2500
Target:  

Fluorescent Dye

Áreas de investigación:  

Others

(Arg)9, FAM-labeled, a cell-penetrating peptide (CPP), is a nona-arginine (ARG) with FAM label. CPPs have emerged as powerful tools for delivering bioactive cargoes into the cytosol of intact cells .
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Cys(Npys)-(Arg)9
Cys(Npys)-(Arg)9
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Referencia número: HY-P4087
No. CAS: 1417221-06-7
Target:  

HIV

Áreas de investigación:  

Infection Cancer

Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .
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