1 Result for "

BSI001

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "BSI001" in MCE Product Catalog:

Cat. No.: HY-P991977
Synonyms: 5G9

Target:  

EGFR Apoptosis PARP Akt ERK

Research Areas:  

Cancer

BSI-001 (5G9) is a HER2-targeting antibody. BSI-001 inhibits cell proliferation and migration, induces apoptosis and PARP cleavage, and suppresses HER2-mediated downstream signaling pathways (including the phosphorylation of EGFR, HER3, AKT and ERK) when combined with Trastuzumab (HY-P9907) in HER2-positive cancer cells. BSI-001 exhibits synergistic anti-tumor efficacy in animal models of gastric cancer and breast cancer when combined with Trastuzumab. BSI-001 can be used for the research of HER2-positive breast cancer and HER2-overexpressing gastric cancer .
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