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Results for "

C26

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Autophagy (6) Bacterial (3) Biochemical Assay Reagents (8) Dihydrofolate reductase (DHFR) (2) Drug Derivative (2) Drug Intermediate (4) ELOVL (1) Endogenous Metabolite (2) Fungal (2) Histone Methyltransferase (1) Insecticide (1) Isotope-Labeled Compounds (4) MEK (1) MMP (3) Raf (1) Reference Standards (3) Renin (6) VEGFR (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (7) Infection (5) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Polymers (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12176

Aliskiren Maximum Cited Publications 11 Publications Verification CGP 60536; CGP60536B; SPP 100	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-12177

Aliskiren hemifumarate Maximum Cited Publications 11 Publications Verification CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-Succinimidyl ester	Biochemical Assay Reagents MMP	Cancer
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

HY-145270

ELOVL1-IN-2	ELOVL	Metabolic Disease
ELOVL1-IN-2 is an elongation of very long chain fatty acid 1 (ELOVL1) enzyme inhibitor, ELOVL1-IN-2 shows weak ELOVL1 inhibition (IC₅₀=21 μM) and moderate potency in a primary cellular assay (HEK293 C26 IC₅₀=6.7 μM) .

HY-160004

PXL770	AMPK	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
PXL770 is an orally active, direct allosteric AMP-activated protein kinase (AMPK) activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters (ABCD2/3) in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet (HFD)-fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy (ALD), autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis (NASH) .

HY-100518

T-26c 3 Publications Verification	MMP	Inflammation/Immunology
T-26c, a chemical probe, is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC₅₀ of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes .

HY-165075S

C26 Sphingomyelin (d18:1/26:0)-d4	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
C26 Sphingomyelin (d18:1/26:0)-d₄ is deuterium labeled C26 Sphingomyelin (d18:1/26:0). C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.

HY-155170

MTDH-SND1 blocker 1	Histone Methyltransferase	Cancer
MTDH-SND1 blocker 1 (compound C26-A6) is an inhibitor of the MTDH-SND1 protein. MTDH-SND1 blocker 1 inhibits cancer metastasis .

HY-W590674

C26-Ceramide	Drug Derivative	Others
C26 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes.

HY-146928S

C26 D,L-Carnitine-d9	Isotope-Labeled Compounds	Others
C26 D,L-Carnitine-d₉ is deuterium labeled C26 D,L-Carnitine.

HY-W096169D

Platinum	Biochemical Assay Reagents Drug Intermediate	Cancer
Platinum is a metallic element, and its complexes act as orally active anticancer agents. Platinum-based complexes used for tumors include Cisplatin (HY-17394), Carboplatin (HY-17393), and Oxaliplatin (HY-17371) .

HY-165075

C26 Sphingomyelin (d18:1/26:0)	Biochemical Assay Reagents	Others
C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.

HY-134127S2

Hexacosanoic acid methyl ester-d3 C26:0 methyl ester-d₃; Ceic acid methyl ester-d₃; Ceotic acid methyl ester-d₃; SFE 27:0-d₃	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Hexacosanoic acid methyl ester-d₃ (C26:0 methyl ester-d₃) is deuterium labeled Methyl hexacosanoate. Methyl hexacosanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-139085A

XL388-C2-amide-PEG9-NH2 hydrochloride	Drug Intermediate	Cancer
XL388-C2-amide-PEG9-NH2 hydrochloride is an intermediate used in the synthesis of C26-linked Rapamycin analog .

HY-139085B

XL388-C2-amide-PEG9-NH2 TFA	Drug Intermediate	Cancer
XL388-C2-amide-PEG9-NH2 TFA is an intermediate used in the synthesis of C26-linked Rapamycin analog .

HY-W777920

C26-Dihydro ceramide	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
C26-Dihydro ceramide is a dihydroceramide containing a C26 very-long-chain fatty acid. C26-Dihydro ceramide can be used for research on various neurological disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, depression, and anxiety disorders .

HY-N4162

3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	Others	Cancer
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia .

HY-173598

T3SS-1-IN-1	Bacterial	Infection
T3SS-1-IN-1 (Compound C26) is a T3SS-1 inhibitor. T3SS-1-IN-1 inhibits the secretion of SipA and the activity of HilD (IC₅₀ values are 29.2 and 16.9 μM, respectively). T3SS-1-IN-1 can be used for the study of anti-virulence of Salmonella .

HY-151459

VEGFR-2/DHFR-IN-2	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer .

HY-162873

MEK/RAF-IN-1	MEK Raf	Cancer
MEK/RAF-IN-1 (Compound 16b) is an inhibitor of both MEK and RAF. It shows potent inhibition with IC₅₀ values of 28 nM for MEK1, and 3 nM each for BRAF and BRAFV600E. MEK/RAF-IN-1 demonstrates significant antitumor activity, effectively inhibiting cell proliferation in vitro against MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Additionally, it inhibits tumor growth in xenograft mouse models of colorectal cancer .

HY-151458

VEGFR-2/DHFR-IN-1	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .

HY-CE00012

(11Z,14Z,17Z,20Z)-Hexacosatetraenoyl-CoA C26:4(Omega-6)-CoA	Biochemical Assay Reagents	Others
(11Z,14Z,17Z,20Z)-Hexacosatetraenoyl-CoA (C26:4(Omega-6)-CoA) is an unsaturated fatty acyl-CoA.

HY-CE00015

(11Z,14Z,17Z,20Z,23Z)-Hexacosapentaenoyl-CoA C26:5(omega-3)-CoA	Biochemical Assay Reagents	Others
(11Z,14Z,17Z,20Z,23Z)-Hexacosapentaenoyl-CoA (C26:5(omega-3)-CoA) is an unsaturated fatty acyl-CoA.

HY-CE00014

(11Z,14Z,17Z,20Z,23Z)-3-Oxohexacosapentaenoyl-CoA 3-Oxo-C26:5(omega-3)-CoA	Biochemical Assay Reagents	Others
(11Z,14Z,17Z,20Z,23Z)-3-Oxohexacosapentaenoyl-CoA (3-Oxo-C26:5(omega-3)-CoA) is an unsaturated fatty acyl-CoA.

HY-178999

Carnosol analog 1	Drug Derivative	Cancer
Carnosol analog 1 (Compound 10) is a derivative of carnosol. Carnosol analog 1 attenuates myotube atrophy (67.08% reversal) and adipocyte lipolysis in C26 tumor-conditioned models. Carnosol analog 1 alleviates cachexia-related weight loss without altering tumor progression in C26 tumor-bearing mice. Carnosol analog 1 can be used for the study of cancer cachexia .

HY-134802

2-Hydroxyhexacosanoic acid	Endogenous Metabolite	Others
2-Hydroxyhexacosanoic acid is a hydroxylated fatty acid. 2-Hydroxyhexacosanoic acid can be obtained from C26 acids by the 2-hydroxylase of Candida utilis .

HY-W673589

Hexacosane, 2-Methyl- 2-Me-C26	Insecticide	Infection
2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, where it contributes to the mating behavior of males, as well as in D. melanogaster females where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.

HY-12176A

Aliskiren hydrochloride CGP 60536 hydrochloride; CGP60536B hydrochloride; SPP 100 hydrochloride	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia ^- .

HY-12176B

Aliskiren fumarate CGP 60536 fumarate; CGP60536B fumarate; SPP 100 fumarate	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren fumarate is an orally active, highly potent and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-12176R

Aliskiren (Standard) CGP 60536 (Standard); CGP60536B (Standard); SPP 100 (Standard)	Reference Standards Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (Standard) is the analytical standard of Aliskiren. This product is intended for research and analytical applications. Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-12177R

Aliskiren hemifumarate (Standard) CGP 60536 hemifumarate (Standard); CGP60536B hemifumarate (Standard); SPP 100 hemifumarate (Standard)	Renin Autophagy Reference Standards	Cardiovascular Disease Cancer
Aliskiren (hemifumarate) (Standard) is the analytical standard of Aliskiren (hemifumarate). This product is intended for research and analytical applications. Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-B0751S

Fumagillin-13C26 Amebacilin-¹³C₂₆; NSC9168-¹³C₂₆	Isotope-Labeled Compounds	Infection
Fumagillin- ¹³C₂₆ (Amebacilin- ¹³C₂₆) is the ¹³C-labeled Fumagillin (HY-B0751). Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

HY-100518R

T-26c (Standard)	MMP Reference Standards	Inflammation/Immunology
T-26c (Standard) is the analytical standard of T-26c (HY-100518). This product is intended for research and analytical applications. T-26c, a chemical probe, is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes .

HY-185585

JNJ-27548547	Drug Intermediate	Cancer
JNJ-27548547, Mitomycin C (HY-13316) prodrug, is a Mitomycin C and lipophilic group conjugate. JNJ-27548547 undergoes thiolytic cleavage of its dithiobenzyl linker in the presence of reducing agents to release active substance Mitomycin C. JNJ-27548547 is formulated into pegylated liposomes (PL-MLP) with high antitumor activity in mice models .

Cat. No.	Product Name	Type

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-Succinimidyl ester	Biochemical Assay Reagents
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

m-PEG2000-NHS ester

mPEG2000-SC; mPEG2000-Succinimidyl ester

Biochemical Assay Reagents

m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

HY-W096169D

Platinum	Biochemical Assay Reagents
Platinum is a metallic element, and its complexes act as orally active anticancer agents. Platinum-based complexes used for tumors include Cisplatin (HY-17394), Carboplatin (HY-17393), and Oxaliplatin (HY-17371) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4162

3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker Cancer Source Classification	Others
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia .

HY-134802

2-Hydroxyhexacosanoic acid	Structural Classification Polyporaceae Ganoderma applanatum Plants Lipid Source Classification	Endogenous Metabolite
2-Hydroxyhexacosanoic acid is a hydroxylated fatty acid. 2-Hydroxyhexacosanoic acid can be obtained from C26 acids by the 2-hydroxylase of Candida utilis .

Cat. No.	Product Name	Chemical Structure

HY-165075S

C26 Sphingomyelin (d18:1/26:0)-d4
C26 Sphingomyelin (d18:1/26:0)-d₄ is deuterium labeled C26 Sphingomyelin (d18:1/26:0). C26 Sphingomyelin (d18:1/26:0) is a biochemical reagent.

HY-146928S

C26 D,L-Carnitine-d9
C26 D,L-Carnitine-d₉ is deuterium labeled C26 D,L-Carnitine.

HY-134127S2

Hexacosanoic acid methyl ester-d3
Hexacosanoic acid methyl ester-d₃ (C26:0 methyl ester-d₃) is deuterium labeled Methyl hexacosanoate. Methyl hexacosanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-B0751S

Fumagillin-13C26
Fumagillin- ¹³C₂₆ (Amebacilin- ¹³C₂₆) is the ¹³C-labeled Fumagillin (HY-B0751). Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.

Cat. No.	Product Name		Classification

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-Succinimidyl ester		Polymers
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

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C26

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products