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Results for "

CCL1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CCR (5) mRNA (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Endocrinology (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Chemokine & Receptors (1) Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122219

R243 3 Publications Verification	CCR	Inflammation/Immunology
R243 is a potent and selective CCR8 antagonist. R243 inhibits *CCL₁/CCR8* interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects ^[1] .

HY-124416

ML604086 1 Publications Verification	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations ^[1] .

HY-P990914

Denikitug GS-1811; JTX-1811	CCR	Inflammation/Immunology Cancer
Denikitug (GS-1811; JTX-1811) is a humanized monoclonal antibody against CCR8 receptor with a K_D of 16.8 pM. Denikitug specifically binds to human CCR8, inhibits CCL1-induced downstream CCR8 signaling. Denikitug selectively depletes cells expressing CCR8 via antibody-dependent cellular cytotoxicity (ADCC). Denikitug promotes anti-tumor immunity and can be used for the research of cancer and immunology ^[1].

HY-144197

CCR8 antagonist 1	CCR	Neurological Disease
CCR8 antagonist 1 (Compound 15) is a potente human CCR8 antagonist with a K_i of 1.6 nM. CCR8 antagonist 1 has high safety and metabolic stability. CCR8 antagonist 1 can be used to study diseases such as asthma and multiple sclerosis ^[1].

HY-174772

*Human CCL1* mRNA**	mRNA	Inflammation/Immunology
Human CCL1 mRNA encodes the human C-C motif chemokine ligand 1 (CCL1) protein, a member of the CC subfamily. CCL1 is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils.

HY-RS16818

Ccl1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl1 Mouse Pre-designed siRNA Set A Ccl1 Mouse Pre-designed siRNA Set A

HY-RS02080

CCL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL1 Human Pre-designed siRNA Set A CCL1 Human Pre-designed siRNA Set A

HY-RS23259

Ccl1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl1 Rat Pre-designed siRNA Set A Ccl1 Rat Pre-designed siRNA Set A

HY-P991944

ZL-1218	CCR	Cancer
ZL-1218 is a selective humanized IgG1 antibody, targeting CCR8. ZL-1218 induces antibody-dependent cellular cytotoxicity (ADCC), leading to NK cell-mediated depletion of CCR8-expressing regulatory T cells (Tregs). ZL-1218 blocks the binding of the CCR8 ligand CCL1 to CCR8 and reduces Treg recruitment by inhibiting the chemotaxis of CCR8 ⁺ cells. ZL-1218 reduces intratumoral Treg levels in a dose-dependent manner. ZL-1218 exerts enhanced antitumor activity when combined with the anti-PD-1 antibody. ZL-1218 can be used for solid tumour research ^[1] .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990914

Denikitug GS-1811; JTX-1811	CCR	Inflammation/Immunology Cancer
Denikitug (GS-1811; JTX-1811) is a humanized monoclonal antibody against CCR8 receptor with a K_D of 16.8 pM. Denikitug specifically binds to human CCR8, inhibits CCL1-induced downstream CCR8 signaling. Denikitug selectively depletes cells expressing CCR8 via antibody-dependent cellular cytotoxicity (ADCC). Denikitug promotes anti-tumor immunity and can be used for the research of cancer and immunology ^[1].

HY-P991944

ZL-1218	CCR	Cancer
ZL-1218 is a selective humanized IgG1 antibody, targeting CCR8. ZL-1218 induces antibody-dependent cellular cytotoxicity (ADCC), leading to NK cell-mediated depletion of CCR8-expressing regulatory T cells (Tregs). ZL-1218 blocks the binding of the CCR8 ligand CCL1 to CCR8 and reduces Treg recruitment by inhibiting the chemotaxis of CCR8 ⁺ cells. ZL-1218 reduces intratumoral Treg levels in a dose-dependent manner. ZL-1218 exerts enhanced antitumor activity when combined with the anti-PD-1 antibody. ZL-1218 can be used for solid tumour research ^[1] .

Recombinant Proteins Recommended:

CCL1

Species:	Human (6) Mouse (1)
Tag:	His (1) Tag Free (3) Avi (1) Fc (3)
Source:	HEK293 (5) CHO (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73913

	*I-309/CCL1* Protein, Mouse (HEK293, Fc)** 2 Publications Verification C-C motif chemokine 1; CCL1; SCYA1; TCA-3	Mouse	HEK293
	I-309/CCL1 Protein, Mouse (HEK293, Fc) is a cytokine that mediates inflammatory immune responses, viral infections, and tumorigenesis by interacting with the CCR8 chemokine receptor on the cell surface and attracting monocytes, natural killer cells, and immature B-cell nuclear dendritic cells. I-309/CCL1 Protein, Mouse (HEK293, Fc) is a recombinant mouse CCL1 (K24-C92) expressed by HEK293 with a -hFc tag at the nitrogen end.

HY-P73914

	*I-309/CCL1* Protein, Human (HEK293, Fc)** C-C motif chemokine 1; CCL1; SCYA1; TCA-3	Human	HEK293
	I-309/CCL1 Protein, Human (HEK293, Fc) is a cytokine that mediates inflammatory immune responses, viral infections, and tumorigenesis by interacting with the CCR8 chemokine receptor on the cell surface and attracting monocytes, natural killer cells, and immature B-cell nuclear dendritic cells. I-309/CCL1 Protein, Human (HEK293, Fc) is a recombinant human CCL1 (K24-K96) expressed by HEK293 with a -hFc tag at the nitrogen end.

HY-P704667

	*I-309/CCL1* Protein, Human (HEK293)** C-C Motif Chemokine 1; Small-Inducible Cytokine A1; T Lymphocyte-Secreted Protein I-309; CCL1; SCYA1	Human	HEK293
	I-309/CCL1 Protein, Human (HEK293) is the recombinant human-derived I-309/CCL1 protein, expressed by HEK293, with tag free tag.

HY-P70463

	*I-309/CCL1* Protein, Human** C-C Motif Chemokine 1; Small-Inducible Cytokine A1; T Lymphocyte-Secreted Protein I-309; CCL1; SCYA1	Human	E. coli
	CCL1 Protein, Human is a cytokine that mediates inflammatory immune responses, viral infections, and tumorigenesis by interacting with the CCR8 chemokine receptor on the cell surface and attracting monocytes, natural killer cells, and immature B-cell nuclear dendritic cells. I-309/CCL1 Protein, Human is a recombinant human CCL1 (K24-K96) expressed by E. coli.

HY-P704666

	*I-309/CCL1* Protein, Human (HEK293, mFc)** C-C Motif Chemokine 1; Small-Inducible Cytokine A1; T Lymphocyte-Secreted Protein I-309; CCL1; SCYA1	Human	HEK293
	I-309/CCL1 Protein, Human (HEK293, mFc) is the recombinant human-derived I-309/CCL1 protein, expressed by HEK293, with C-mFc tag.

HY-P705140

	*I-309/CCL1* Protein, Human (Biotinylated, HEK293, His-Avi)** C-C Motif Chemokine 1; Small-Inducible Cytokine A1; T Lymphocyte-Secreted Protein I-309; CCL1; SCYA1	Human	HEK293

HY-P7198

	*I-309/CCL1* Protein, Human (CHO)** 1 Publications Verification rHuI-309/CCL1; C-C motif chemokine 1; SCYA1	Human	CHO
	I-309/CCL1 Protein, Human (CHO) is a cytokine that mediates inflammatory immune responses, viral infections, and tumorigenesis by interacting with the CCR8 chemokine receptor on the cell surface and attracting monocytes, natural killer cells, and immature B-cell nuclear dendritic cells. I-309/CCL1 Protein, Human (CHO) is a recombinant human CCL1 (K24-K96) expressed by CHO.

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*Human CCL1* mRNA**		mRNA Chemokine & Receptors
Human CCL1 mRNA encodes the human C-C motif chemokine ligand 1 (CCL1) protein, a member of the CC subfamily. CCL1 is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils.

Ccl1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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