47 Results for "

CD206+

" in MedChemExpress (MCE) Product Catalog:
Products (47)

47 Results for "CD206+" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P81214
Synonyms: Mannose Receptor; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Rat

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1
1 Cited Publications
Cat. No.: HY-P83714M
Synonyms: MMR; MR; MRC1; macrophage mannose receptor; mannose receptor

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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1
1 Cited Publications
Cat. No.: HY-P86350
Synonyms: MRC1; CLEC13D; CLEC13DL; MRC1L1; Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD206

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-160421
CAS No.: 2000236-36-0
Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 + and CX3CR1 + immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .
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Cat. No.: HY-148591
Purity:  99.64%
Research Areas:  

Inflammation/Immunology

GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of CD206 + regulatory macrophages by inhibiting SP140 .
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Cat. No.: HY-P11108
CAS No.: 1895883-60-9
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research .
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Cat. No.: HY-N14001
CAS No.: 2227550-73-2
Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors .
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Cat. No.: HY-P11107
CAS No.: 2375823-45-1
Target:  

Apoptosis TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

RP-832c is a synthetic analogue of host defense peptides (HDP), targeting the mannose receptor CD206 on the surface of M2 polarized macrophages (Kd = 3.5 μM). RP-832c binding to CD206 induces a significant conformational change in the receptor, activating signaling pathways that lead to rapid apoptosis and repolarization of CD206-positive M2 macrophages to an M1 phenotype. RP-832c treatment significantly reduces CD206 gene expression in M2 macrophages while transiently increasing expression of TNF-α, a marker for M1 macrophages. RP-832c is used for the studies of T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF) .
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Cat. No.: HY-P10894
CAS No.: 2283322-63-2
Research Areas:  

Cancer

mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to mouse CD206, targeting tumor-associated macrophages that express CD206/MRC1. mUNO can interact with human recombinant CD206 .
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Cat. No.: HY-169089
Target:  

Drug Derivative

Research Areas:  

Cancer

RP-182-PEG3-K palmitic acid-NH2 (Compound 1a) is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K palmitic acid-NH2 inhibits CD206 high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K palmitic acid-NH2 exhibits antitumor efficacy in mouse B16 melanoma allografts .
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Cat. No.: HY-P11108A
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .
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Cat. No.: HY-P10947
Research Areas:  

Cancer

MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. MACTIDE-V delivers Verteporfin (HY-B0146) to CD206 + tumor-associated macrophages (TAM) to inhibit the YAP/TAZ signaling pathway, prompting YAP exclusion from the nucleus, inducing TAM polarization toward an anti-tumoral phenotype with enhanced phagocytosis and antigen presentation, and boosting T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models .
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Cat. No.: HY-169089A
Target:  

Drug Derivative

Research Areas:  

Cancer

RP-182-PEG3-K(palmitic acid)-NH2 (Compound 1a) TFA is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K(palmitic acid)-NH2 TFA inhibits CD206 high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K(palmitic acid)-NH2 TFA exhibits antitumor efficacy in mouse B16 melanoma allografts .
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Cat. No.: HY-P11217
CAS No.: 3103331-32-1
Research Areas:  

Cancer

MACTIDE is a CD206 targeting peptide with high affinity and stability. MACTIDE is commonly used to enhance the targeting of drugs. MACTIDE can be used in the research of cancer such as breast cancer .
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Cat. No.: HY-D2978
CAS No.: 3038636-76-6
MR2-cy5 is a fluorescent agent. MR2-cy5 is highly specific to CD206. MR2-cy5 can track CD206 + macrophages .
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Cat. No.: HY-RS08641
Research Areas:  

Others

MRC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MRC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P705166
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMR; CD206; hMR; MRC1; CLEC13D; CLEC13DL; MRC1L1
Species:  
Source:  
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Cat. No.: HY-P78736
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MMR; CD206; hMR; MRC1; CLEC13D; CLEC13DL; MRC1L1
Species:  
Source:  
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Cat. No.: HY-P8F038A
Synonyms: CD206,CD206-FITC,15-2

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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Cat. No.: HY-P8F038C
Synonyms: CD206,CD206-PE,15-2

Host:  

Mouse

Application:  

FC

Reactivity:  

Human

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