CD206/MMR Protein, Human (Biotinylated, HEK293, His)
The CD206/MMR protein acts as a multifunctional mediator in macrophages, promoting glycoprotein internalization. It has a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. CD206/MMR Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived CD206/MMR protein, expressed by HEK293, with C-Avi;C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The CD206/MMR protein acts as a multifunctional mediator in macrophages, promoting glycoprotein internalization. It has a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. CD206/MMR Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived CD206/MMR protein, expressed by HEK293, with C-Avi;C-His labeled tag.
Background
CD206/MMR Protein plays a pivotal role in cellular processes, acting as a versatile mediator of endocytosis in macrophages, specifically facilitating the internalization of glycoproteins. The protein exhibits a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. In the context of microbial infection, CD206/MMR further assumes a critical role as a phagocytic receptor, contributing to the recognition and engulfment of bacteria, fungi, and other pathogens. This multifaceted functionality underscores CD206/MMR's significance in orchestrating the cellular response to glycoproteins and microbial challenges, showcasing its role as a key player in innate immunity and cellular homeostasis.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
P22897-1 (L19-A1389)
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Gene ID4360
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Molecular Construction
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N-term
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CD206 (L19-A1389)
Accession # P22897-1 -
His
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C-term
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Protein Length
Extracellular Domain
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Conjugation
Biotin
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Synonyms
MRC1; Macrophage Mannose Receptor 1; Prev. MRC1L1; MMR; CLEC13DL; HMR; CLEC13D; C-Type Lectin Domain Family 13 Member D-Like; BA541I19.1; Macrophage Mannose Receptor; CD206; Mannose Receptor, C Type 1; Macrophage Mannose Receptor 1-Like Protein 1; Alterna
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AA Sequence
LLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGCVAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVA
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Predicted Molecular Mass
158.6 kDa
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Molecular Weight
Approximately 170-210 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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