1 Result for "

CI 979 hydroiodide

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "CI 979 hydroiodide" in MCE Product Catalog:

Cat. No.: HY-107650A
Purity:  96.25%
Synonyms: CI 979 hydroiodide; RU 35926 hydroiodide
Target:  

mAChR

Research Areas:  

Neurological Disease

Milameline (CI 979; RU35926) hydroiodide is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydroiodide has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydroiodide has a higher affinity for sites [ 3H]CMD (IC50 = 20 nM), than [ 3H]QNB, (IC50 = 3059 nM). Milameline hydroiodide produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydroiodide can be used for the study of Alzheimer’s Disease .
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