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DMD

" in MedChemExpress (MCE) Product Catalog:

34

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Inhibitory Antibodies

1

Natural
Products

1

Antibodies

19

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14842
    Givinostat
    Maximum Cited Publications
    11 Publications Verification

    ITF-2357

    		 HDAC Inflammation/Immunology Cancer
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research. Givinostat can penetrate the blood-brain barrier (BBB) .
    Givinostat
  • HY-152182
    ML-SA5
    4 Publications Verification

    		 TRP Channel Cancer
    ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth .
    ML-SA5
  • HY-108753
    Eteplirsen

    AVI 4658

    		 Arp2/3 Complex Metabolic Disease
    Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide. Eteplirsen can be used for Duchenne muscular dystrophy research .
    Eteplirsen
  • HY-132611
    Golodirsen

    SRP-4053

    		 Dystrophin DNA/RNA Synthesis Neurological Disease
    Golodirsen (SRP-4053) is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen can restore the expression of the anti-myostatin protein. Golodirsen can be used for the research of duchenne muscular dystrophy (DMD) .
    Golodirsen
  • HY-P990051
    Delpacibart

    AOC-1001 Antibody; AOC-1044 Antibody

    		 Transferrin Receptor Neurological Disease Inflammation/Immunology
    Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
    Delpacibart
  • HY-132586
    Viltolarsen

    NS-065/NCNP-01

    		 Nucleoside Antimetabolite/Analog Dystrophin Metabolic Disease
    Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen has the potential for Duchenne muscular dystrophy (DMD) research .
    Viltolarsen
  • HY-127137
    Adenylosuccinic acid

    Adenylosuccinate; Aspartyl adenylate

    		 Endogenous Metabolite Metabolic Disease
    Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD) .
    Adenylosuccinic acid
  • HY-15898
    Y-320
    5 Publications Verification

    		 Interleukin Related Apoptosis Inflammation/Immunology Cancer
    Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
    Y-320
  • HY-147332
    TCL053

    		Liposome Neurological Disease
    TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
    TCL053
  • HY-P99857
    Domagrozumab

    PF-06252616

    		 TGF-beta/Smad Metabolic Disease
    Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD) .
    Domagrozumab
  • HY-17614
    Ezutromid

    SMT C1100; BMN 195; VOX-C1100

    		 Cytochrome P450 Others
    Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM .
    Ezutromid
  • HY-132611A
    Golodirsen sodium

    SRP-4053 sodium

    		 DNA/RNA Synthesis Dystrophin Neurological Disease
    Golodirsen (SRP-4053) sodium is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen sodium restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen sodium can restore the expression of the anti-myostatin protein. Golodirsen sodium can be used for the research of duchenne muscular dystrophy (DMD) .
    Golodirsen sodium
  • HY-134377
    Bocidelpar

    ASP0367; MA-0211

    		 PPAR Metabolic Disease
    Bocidelpar (ASP0367; MA-0211) is a selective, orally active PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD) .
    Bocidelpar
  • HY-132586A
    Viltolarsen sodium

    NS-065/NCNP-01 sodium

    		 Nucleoside Antimetabolite/Analog Dystrophin Metabolic Disease
    Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research .
    Viltolarsen sodium
  • HY-122631
    TG693

    		CDK Dystrophin Others
    TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research .
    TG693
  • HY-RS03823
    DMD Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DMD Human Pre-designed siRNA Set A contains three designed siRNAs for DMD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DMD Human Pre-designed siRNA Set A
    DMD Human Pre-designed siRNA Set A
  • HY-147253
    Brogidirsen

    NS 089; NCNP 02

    		 DNA/RNA Synthesis Neurological Disease
    Brogidirsen (NS 089; NCNP 02) is a a dual-targeting antisense oligonucleotide. Brogidirsen can induce dystrophin protein experession. Brogidirsen can be used for the research of Duchenne muscular dystrophy .
    Brogidirsen
  • HY-101459
    RTC13

    		Dystrophin Metabolic Disease
    RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD) .
    RTC13
  • HY-127137A
    Adenylosuccinic acid tetraammonium

    Adenylosuccinate tetraammonium; Aspartyl adenylate tetraammonium

    		 Endogenous Metabolite Metabolic Disease
    Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD) .
    Adenylosuccinic acid tetraammonium
  • HY-114739
    MA-0204

    		PPAR Metabolic Disease
    MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD) .
    MA-0204
  • HY-139972
    PROTAC(H-PGDS)-7

    		Molecular Glues Prostaglandin Receptor Cardiovascular Disease
    PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM .
    PROTAC(H-PGDS)-7
  • HY-14842R
    Givinostat (Standard)

    ITF-2357 (Standard)

    		 HDAC Reference Standards Inflammation/Immunology Cancer
    Givinostat (Standard) is the analytical standard of Givinostat. This product is intended for research and analytical applications. Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research .
    Givinostat (Standard)
  • HY-153369
    BAY-747

    BAY 1165747

    		 Guanylate Cyclase Cardiovascular Disease Neurological Disease
    BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model .
    BAY-747
  • HY-150077
    Utrophin modulator 1

    		Microtubule/Tubulin Others
    Utrophin modulator 1 is a potent utrophin modulator (upregulates utrophin protein levels), with an EC50 of 0.11 μM. Utrophin modulator 1 can be used in study of duchenne muscular dystrophy (DMD) .
    Utrophin modulator 1
  • HY-122588A
    Negamycin hydrochloride

    		Antibiotic Cardiovascular Disease Metabolic Disease
    Negamycin (hydrochloride) is a dipeptide antibiotic. Negamycin (hydrochloride) can restore dystrophin expression in skeletal and cardiac muscles in mdx Duchenne muscular dystrophy (DMD) murine model. Negamycin (hydrochloride) can bind to a partial sequence of the eukaryotic rRNA-decoding A-site. Negamycin (hydrochloride) can be studied in DMD research .
    Negamycin hydrochloride
  • HY-177659
    Rimigorsen

    		Dystrophin Others
    Rimigorsen is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
    Rimigorsen
  • HY-RS18019
    Dmd Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dmd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dmd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dmd Mouse Pre-designed siRNA Set A
    Dmd Mouse Pre-designed siRNA Set A
  • HY-RS24492
    Dmd Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dmd Rat Pre-designed siRNA Set A contains three designed siRNAs for Dmd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dmd Rat Pre-designed siRNA Set A
    Dmd Rat Pre-designed siRNA Set A
  • HY-150078
    OX01914

    		Microtubule/Tubulin Others
    OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD) .
    OX01914
  • HY-177659A
    Rimigorsen sodium

    		Dystrophin Others
    Rimigorsen sodium is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
    Rimigorsen sodium
  • HY-150237
    FITC-labeled Drisapersen sodium

    		DNA/RNA Synthesis Dystrophin Others
    FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
    FITC-labeled Drisapersen sodium
  • HY-14931
    Naproxcinod

    AZD 3582; HCT 3012; Nitronaproxen

    		 COX Inflammation/Immunology
    Naproxcinod (Nitronaproxen) is the first in class of cyclooxygenase (COX)-inhibiting nitric oxide donators (CINODs). Naproxcinod shows analgesic and anti-inflammatory effects, it can be used for the research of osteoarthritis and inflammation .
    Naproxcinod
  • HY-17614R
    Ezutromid (Standard)

    SMT C1100 (Standard); BMN 195 (Standard); VOX-C1100 (Standard)

    		 Cytochrome P450 Reference Standards Others
    Ezutromid (Standard) is the analytical standard of Ezutromid. This product is intended for research and analytical applications. Ezutromid (SMT C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM. Ezutromid can be used for the research Duchenne muscular dystrophy (DMD). Ezutromid inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM .
    Ezutromid (Standard)
  • HY-101459R
    RTC13 (Standard)

    		Dystrophin Reference Standards Metabolic Disease
    RTC13 (Standard) is the analytical standard of RTC13 (HY-101459). This product is intended for research and analytical applications. RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD) .
    RTC13 (Standard)

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