55 Results for "

DNA Nanoparticles

" in MedChemExpress (MCE) Product Catalog:
Products (55)

55 Results for "DNA Nanoparticles" in MCE Product Catalog:

26
mPEG2000-DMG
mPEG2000-DMG
0 Images
26 Cited Publications
Cat. No.: HY-112764
CAS No.: 160743-62-4
Purity:  98.40%
mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
loading...
    loading...
View All Sizes
DSPE-PEG1000-Amine ammonium
DSPE-PEG1000-Amine ammonium
0 Images
Cat. No.: HY-W440823A
CAS No.: 474922-26-4
Synonyms: DSPE-PEG1000-NH2 ammonium
DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules .
loading...
    loading...
View All Sizes
Dextran T4 (MW 4,000)
Dextran T4 (MW 4,000)
0 Images
Cat. No.: HY-112624J
CAS No.: 9004-54-0
Synonyms: Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)
Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
loading...
    loading...
View All Sizes
m-PEG1000-thiol
m-PEG1000-thiol
0 Images
Cat. No.: HY-W591476
CAS No.: 134874-49-0
Synonyms: mPEG1000-SH
m-PEG1000-thiol (mPEG1000-SH) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG1000-thiol can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG1000-thiol can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials [2].
loading...
    loading...
View All Sizes
L17E
L17E
0 Images
Cat. No.: HY-P4121
CAS No.: 1898254-09-5
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
loading...
    loading...
View All Sizes
NIR-Red Dead Cell-1 Dye
NIR-Red Dead Cell-1 Dye
0 Images
Cat. No.: HY-D0917
CAS No.: 157199-59-2
NIR-Red Dead Cell-1 Dye is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). NIR-Red Dead Cell-1 Dye can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. NIR-Red Dead Cell-1 Dye is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. NIR-Red Dead Cell-1 Dye can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. NIR-Red Dead Cell-1 Dye can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies .
loading...
    loading...
View All Sizes
Poly-L-lysine hydrobromide (MW 1000-5000)
Poly-L-lysine hydrobromide (MW 1000-5000)
0 Images
Cat. No.: HY-126437I
CAS No.: 25988-63-0
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .
loading...
    loading...
View All Sizes
Dextran T5 (MW 5,000)
Dextran T5 (MW 5,000)
0 Images
Cat. No.: HY-112624K
CAS No.: 9004-54-0
Synonyms: Dextran 5; Dextran D5; Dextran T5(MW 4500-5500)
Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
loading...
    loading...
View All Sizes
DSPE-m-PEG3400-NHS
DSPE-m-PEG3400-NHS
0 Images
Cat. No.: HY-W441015A
DSPE-m-PEG3400-NHS is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine .
loading...
    loading...
View All Sizes
Depressine
Depressine
0 Images
Cat. No.: HY-N5070
CAS No.: 176182-06-2
Synonyms: Depressin
Category:  

other families Monophenols Other Diseases Phenols Plants Disease Research Fields

Target:  

Biochemical Assay Reagents

Depressine is an iridoid glycoside that can be isolated from the methanol extract of the aerial parts of Gentiana depressa. Depressine can be used to reduce oxidative DNA base damage and strand breaks that are prone to occur during the preparation of silver nanoparticles (AgNPs) .
loading...
    loading...
View All Sizes
5-PA-dUTP
5-PA-dUTP
0 Images
Cat. No.: HY-132141
CAS No.: 179101-49-6
Purity:  99.59%
Synonyms: 5-Propargylamino-dUTP
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
loading...
    loading...
View All Sizes
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine
0 Images
Cat. No.: HY-W583869
CAS No.: 6418-95-7
Synonyms: 1-Stearoyl-2-Oleoyl-sn-glycero-3-PE; 18:0-18:1 PE; PE(18:0/18:1)
Target:  

Liposome

Research Areas:  

Metabolic Disease

1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.
loading...
    loading...
View All Sizes
DSPE-PEG-Amine, MW 3400 ammonium
DSPE-PEG-Amine, MW 3400 ammonium
0 Images
Cat. No.: HY-155887
CAS No.: 474922-26-4
Synonyms: DSPE-PEG-NH2, MW 3400 ammonium
DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research .
loading...
    loading...
View All Sizes
Celestine Blue
Celestine Blue
0 Images
Cat. No.: HY-D0948
CAS No.: 1562-90-9
Celestine Blue is a electroactive indicator in DNA biosensors. Celestine Blue is strongly adsorbed on the spinel phases and CNT (carbon nanotubes), facilitates dispersion, acts as a capping agent and allows for the fabrication of spinel decorated CNT. Celestine Blue is an efficient charge transfer mediator, which allows for significant improvement of capacitive behavior. TiO2 nanoparticles doped with Celestine Blue can be used as a label in a sandwich immunoassay for the hepatitis C virus (HCV) core antigen .
loading...
    loading...
View All Sizes
DSPE-PEG5000-azide
DSPE-PEG5000-azide
0 Images
Cat. No.: HY-W440834
DSPE-PEG5000-azide is a click chemistry reactive phospholipid polyPEG which forms lipid bilayer or micelles in an aqueous solution. The polymer can be used to prepare liposomes or nanoparticles used for delivering nutrients or therapeutic agents, for example mRNA or DNA vaccine.
loading...
    loading...
View All Sizes
DSPE-PEG5000-Cy3
DSPE-PEG5000-Cy3
0 Images
Cat. No.: HY-W440910
DSPE-PEG5000-Cy3 is a phospholipid PEG polymer with Cy3 dye used in labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
loading...
    loading...
View All Sizes
Cy7.5-PEG2000-DSPE
Cy7.5-PEG2000-DSPE
0 Images
Cat. No.: HY-D2593
Cy7.5-PEG2000-DSPE is a PEG phospholipid with CY7.5 (HY-D0926) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy7.5-PEG2000-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=770/820 nm).
loading...
    loading...
View All Sizes
N-(4-Formylphenyl)acetamide
N-(4-Formylphenyl)acetamide
0 Images
Cat. No.: HY-W067445
CAS No.: 122-85-0
Synonyms: 4-Acetamidobenzaldehyde
N-(4-Formylphenyl) acetamide (4-Acetamidobenzaldehyde) is an organic ligand bearing aldehyde and acetamide functional groups. N-(4-Formylphenyl) acetamide can be used to functionalize Fe3O4@SiO2 nanoparticles for selective fluorescence quenching detection of Hg 2+. N-(4-Formylphenyl) acetamide serves as a precursor for the synthesis of benzimidazole, benzothiazole and Schiff base derivatives, which exhibit antioxidant, AChE/BChE inhibitory and DNA-binding activities. N-(4-Formylphenyl) acetamide can be applied in studies related to Alzheimer's disease .
loading...
    loading...
View All Sizes
DSPE-PEG3400-Cy5
DSPE-PEG3400-Cy5
0 Images
Cat. No.: HY-W440912
DSPE-PEG3400-Cy5 is a PEG phospholipid with Cy5 dye used in protein/nucelic acid labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.
loading...
    loading...
View All Sizes
mPEG2000-DMG (GMP Like)
mPEG2000-DMG (GMP Like)
0 Images
Cat. No.: HY-112764GL
CAS No.: 160743-62-4
mPEG2000-DMG (GMP Like) is mPEG2000-DMG (HY-112764) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
loading...
    loading...
View All Sizes
Assay Types