1898254-09-5
Chemical Structure
L17E
- CAS No.: 1898254-09-5
- Formula:C134H220N38O31
- Molecular Weight:2859.42
IUPAC Name: 5,7-dihydroxy-2-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)-4H-chromen-4-one
SMILES: CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H]([C@H](CC)C)N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O)C)=O)CC(C)C)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)=O)CCCCN)=O)CC4=CN=CN4)=O)C)=O)C)=O)CCCCN)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)C(N)=O)C
Biological Activity: L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L17E | 99.88% | L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles. | ||||||||||||||||||||
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- [1]. Dogan Can Kirman, et al. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis. 2022 Feb 23;13(2):172. [Content Brief]
- [2]. Akishiba M, et al. Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide. Nat Chem. 2017 Aug;9(8):751-761. [Content Brief]
- [3]. Nomura Y, et al. Improved cytosolic delivery of macromolecules through dimerization of attenuated lytic peptides. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127362. [Content Brief]
- [4]. He, Jinjun, et al. Coating tetrahedral DNA framework with endosomolytic peptides for improved stability and cytosolic delivery. Advanced Sensor and Energy Materials 3.2 (2024): 100098.
- [5]. Du W, et al. Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy. Biomaterials. 2023 Mar;294:122000. [Content Brief]
- [6]. Kuriyama M, et al. KCNN4 as a genomic determinant of cytosolic delivery by the attenuated cationic lytic peptide L17E. Mol Ther. 2025 Feb 5;33(2):595-614. [Content Brief]
Keywords
