2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 5-PA-dUTP

5-PA-dUTP  (Synonyms: 5-Propargylamino-dUTP)

Cat. No.: HY-132141 Purity: ≥98.0%
COA Handling Instructions

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5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery. 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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5-PA-dUTP Chemical Structure

5-PA-dUTP Chemical Structure

CAS No. : 179101-49-6

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Solvent
52.12mg (100 mM * 1 mL in Triethylamine) USD 2380 In-stock
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Based on 1 publication(s) in Google Scholar

5-PA-dUTP Related Antibodies

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Description

5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery[1]. 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

521.20

Formula

C12H18N3O14P3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1N([C@H]2C[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)C=C(C(N1)=O)C#CCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (239.83 mM; Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9186 mL 9.5932 mL 19.1865 mL 47.9662 mL
5 mM 0.3837 mL 1.9186 mL 3.8373 mL 9.5932 mL
10 mM 0.1919 mL 0.9593 mL 1.9186 mL 4.7966 mL
15 mM 0.1279 mL 0.6395 mL 1.2791 mL 3.1977 mL
20 mM 0.0959 mL 0.4797 mL 0.9593 mL 2.3983 mL
25 mM 0.0767 mL 0.3837 mL 0.7675 mL 1.9186 mL
30 mM 0.0640 mL 0.3198 mL 0.6395 mL 1.5989 mL
40 mM 0.0480 mL 0.2398 mL 0.4797 mL 1.1992 mL
50 mM 0.0384 mL 0.1919 mL 0.3837 mL 0.9593 mL
60 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7994 mL
80 mM 0.0240 mL 0.1199 mL 0.2398 mL 0.5996 mL
100 mM 0.0192 mL 0.0959 mL 0.1919 mL 0.4797 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5-PA-dUTP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-PA-dUTP179101-49-65-Propargylamino-dUTPDNA/RNA SynthesisNucleotidedUTP,C5-modifiedInhibitorinhibitorinhibit

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