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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Disulfidptosis
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Disulfidptosis" in MCE Product Catalog:
878
878 Publications Verification
Target:
Research Areas:
Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .
735
735 Cited Publications
Synonyms: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
59
59 Cited Publications
Target:
Research Areas:
BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .
45
45 Cited Publications
Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
6
6 Cited Publications
Target:
Research Areas:
KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .
Cat. No.: HY-B0215S
CAS No.: 131685-11-5
Synonyms: N-Acetylcysteine-d3; N-Acetyl-L-cysteine-d3; NAC-d3
Cat. No.: HY-15917S2
CAS No.: 850153-85-4
Synonyms: DTT-d6
Synonyms: N-Acetylcysteine (Standard); N-Acetyl-L-cysteine (Standard); NAC (Standard)
Cat. No.: HY-15917S
CAS No.: 302912-05-6
Synonyms: DTT-d10
Cat. No.: HY-B0215S1
Synonyms: N-Acetylcysteine-15N; N-Acetyl-L-cysteine-15N; NAC-15N
Cat. No.: HY-15917S1
CAS No.: 203633-21-0
Synonyms: DTTl-d10-1
Cat. No.: HY-100017R
CAS No.: 1799753-84-6
Target:
Research Areas:
BAY-876 (Standard) is the analytical standard of BAY-876 (HY-100017). This product is intended for research and analytical applications. BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
