991 Results for "

Drug derivative

" in MedChemExpress (MCE) Product Catalog:
Products (991)

991 Results for "Drug derivative" in MCE Product Catalog:

61
61 Publications Verification
Cat. No.: HY-15162
CAS No.: 474645-27-7
Purity:  99.97%
Synonyms: MMAE; SGD-1010
Research Areas:  

Cancer

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
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32
32 Cited Publications
Cat. No.: HY-13631E
CAS No.: 1599440-13-7
Purity:  99.94%
Synonyms: MC-GGFG-DXD
Research Areas:  

Cancer

Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .
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14
14 Cited Publications
Cat. No.: HY-13631D
CAS No.: 1599440-33-1
Purity:  99.30%
Synonyms: Exatecan derivative for ADC
Research Areas:  

Cancer

DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
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7
7 Cited Publications
Cat. No.: HY-P9921A
CAS No.: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer .
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3
3 Cited Publications
Cat. No.: HY-W441014
DSPE-PEG2000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG2000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG2000-NHS can be used in the study of drug delivery .
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2
2 Cited Publications
Cat. No.: HY-170706
CAS No.: 1445832-74-5
Target:  

Liposome

Research Areas:  

Cancer

DSPE-PEG2000-NHCO-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (HY-112530) . DSPE-PEG2000-NHCO-COOH can form micelles for targeted drug delivery .
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1
1 Cited Publications
Cat. No.: HY-Y0267
CAS No.: 122-59-8
Phenoxyacetic acid is a multifunctional drug prodrug or auxin-type growth regulator, and its derivatives have insecticidal, herbicidal and antifungal activities .
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1
1 Cited Publications
Cat. No.: HY-W007466
CAS No.: 504-02-9
Cyclohexane-1,3-dione is a drug intermediate, and its derivatives can exhibit significant tyrosine kinase inhibitory activity and anti-tumor activity .
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1
1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
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1
1 Cited Publications
Cat. No.: HY-N7135
CAS No.: 533-75-5
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .
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1
1 Cited Publications
Cat. No.: HY-W010712
CAS No.: 109425-51-6
Research Areas:  

Others

Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
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Cat. No.: HY-W440702
Cholesterol-PEG2000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-NHS can be used in drug delivery research .
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Cat. No.: HY-167064
Synonyms: DSPE-Polysarcosine50
DSPE-pSar50 (DSPE-Polysarcosine50) is a pSar-lipid derivative. DSPE-pSar50 is a hydrophilic alternative to PEG and can be used in drug delivery research .
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Cat. No.: HY-167065
Synonyms: DSPE-Polysarcosine20
DSPE-pSar20 (DSPE-Polysarcosine20) is a pSar-lipid derivative. DSPE-pSar20 is a hydrophilic alternative to PEG and can be used in drug delivery research .
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Cat. No.: HY-W440697
Cholesterol-PEG1000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-NHS can be used in drug delivery research .
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Cat. No.: HY-167067
Synonyms: DSPE-Polysarcosine100
DSPE-pSar100 (DSPE-Polysarcosine100) is a pSar-lipid derivative. DSPE-pSar100 is a hydrophilic alternative to PEG and can be used in drug delivery research .
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Cat. No.: HY-W423643
CAS No.: 1225617-75-3
Target:  

Drug Derivative

Research Areas:  

Neurological Disease

Benzedrone is a synthetic drug derivative. Benzedrone can increase the levels of neurotransmitters such as dopamine, serotonin and norepinephrine in the brain, thus producing a stimulant effect. Benzedrone can be used in the research of new psychoactive substances (NPS) .
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Cat. No.: HY-167063
Synonyms: Azide-Polysarcosine20
Azide-pSar20 (Azide-Polysarcosine20) is a pSar-lipid derivative. Azide-pSar20 is a hydrophilic alternative to PEG and can be used in drug delivery research .
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Cat. No.: HY-W440704
Cholesterol-PEG5000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-NHS can be used in drug delivery research .
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Cat. No.: HY-W440718
Cholesterol-PEG1000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Mal can be used in drug delivery research .
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