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FSP1-IN-1

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By Targets:	ACSL Family (1) Ferroptosis (6) Glutathione Peroxidase (1) Ligands for Target Protein for PROTAC (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Transferrin Receptor (1)
By Research Areas:	Cancer (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136057

iFSP1 Maximum Cited Publications 29 Publications Verification	Ferroptosis Ligands for Target Protein for PROTAC	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-153629

FSEN1 2 Publications Verification	Ferroptosis	Cancer
FSEN1 is a potent and non-competitive *FSP1* inhibitor with an IC₅₀ value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer .

HY-163002

viFSP1 4 Publications Verification	Ferroptosis	Cancer
viFSP1 is a species-independent *FSP1* inhibitor. viFSP1 directly inhibits FSP1 by targeting the highly conserved NAD(P)H binding pocket of FSP1. viFSP1 can induce Ferroptosis in FSP1-dependent cells. viFSP1 can be used in renal and breast cancer research .

HY-172896

*FSP1-IN-1*	Ferroptosis	Cancer
FSP1-IN-1 (compound 39) is a potent *FSP1* inhibitor with an IC₅₀ of 35 nM. FSP1-IN-1 enhances RSL3 (HY-100218A)-induced lipid peroxide accumulation and sensitizes cancer cells to ferroptosis .

HY-179384

PROTAC FSP1 degrader 1	ACSL Family PROTACs Ferroptosis Glutathione Peroxidase Transferrin Receptor Reactive Oxygen Species (ROS)	Cancer
PROTAC FSP1 degrader 1 is a highly efficient and selective PROTAC degrader targeting *FSP1. PROTAC FSP1 degrader 1* significantly induces the accumulation of intracellular lipid peroxides. PROTAC FSP1 degrader 1 exhibits synergistic induction of ferroptosis with GPX4 inhibitors. PROTAC FSP1 degrader 1 can induce ROS production. PROTAC FSP1 degrader 1 upregulates the mRNA expression of ferroptosis-related proteins (GPX4, FTH1, ACSL4, TfR1, FSP1). PROTAC FSP1 degrader 1 can be used for the study of triple-negative breast cancer .

HY-175738

afi-FSP1-1	Ferroptosis	Cancer
afi-FSP1-1 is a Ferroptosis suppressor protein 1 (FSP1) inhibitor with an K_i of 0.283  μM. afi-FSP1-1 has a superior binding capacity to FSP1-FAD-NAD ⁺. afi-FSP1-1 can induces ferroptosis in cancer cells. afi-FSP1-1 can be used for cancers research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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FSP1-IN-1

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