951945-67-8
951945-67-8
Chemical Structure
viFSP1
- CAS No.: 951945-67-8
- Formula:C16H17N3O3S
- Molecular Weight:331.39
InChIKey: OUJMVDXLUWMMEC-UHFFFAOYSA-N
SMILES: O=C1C(C2=NC(C)=CS2)=C(N(C1)C3=CC=C(C=C3OC)OC)N
Biological Activity: viFSP1 is a species-independent FSP1 inhibitor. viFSP1 directly inhibits FSP1 by targeting the highly conserved NAD(P)H binding pocket of FSP1. viFSP1 can induce Ferroptosis in FSP1-dependent cells. viFSP1 can be used in renal and breast cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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viFSP1 | 99.50% | viFSP1 is a species-independent FSP1 inhibitor. viFSP1 directly inhibits FSP1 by targeting the highly conserved NAD(P)H binding pocket of FSP1. viFSP1 can induce Ferroptosis in FSP1-dependent cells. viFSP1 can be used in renal and breast cancer research. | ||||||||||||||||||||
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Flaviviruses-IN-1 | Flaviviruses-IN-1 is an inhibitor of several viruses belonging to the Flaviviridae family, with activity to inhibit viral infection. Flaviviruses-IN-1 is able to specifically inhibit multiple viruses of the Flaviviridae family. The mechanism of action of Flaviviruses-IN-1 is related to the modulation of the host cell immune response to viral infection. Flaviviruses-IN-1 was identified as a potential candidate compound in a high-throughput screening. Flaviviruses-IN-1 provides a new strategy for inhibiting infections caused by the Flaviviridae family. | |||||||||||||||||||||
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SLK/STK10-IN-1 | 99.78% | SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with antitumor activity. | ||||||||||||||||||||
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PQ401 | 99.85% | PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis. | ||||||||||||||||||||
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ETNK-IN-2 | ETNK-IN-2 (Compound 8) is an inhibitor of ethanolamine kinase (ETNK) with an IC50 value of ≥ 5 μM, which can be used in research for insecticide development. | |||||||||||||||||||||
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Anti-inflammatory agent 102 | Anti-inflammatory agent 102 (Compound 11a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 102 exerts its anti-inflammatory effect by blocking the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. Anti-inflammatory agent 102 has significant anti-inflammatory activity and can inhibit the release of NO, ROS, and inflammatory factors (such as IL-6, TNF-α, IL-1β). Anti-inflammatory agent 102 can be used in the study of inflammatory diseases such as ulcerative colitis (UC). | |||||||||||||||||||||
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HDAC6-IN-84 | HDAC6-IN-84 is a potent and selective HDAC6 inhibitor with an IC50 of 25.56 nM and shows 478-fold selectivity over HDAC1. HDAC6-IN-84 increases α-tubulin acetylation and upregulates BDNF (exons I and IV) and other neurogenesis-related genes. HDAC6-IN-84 can be used for the study of Alzheimer’s disease (AD) and other neurodegenerative diseases. | |||||||||||||||||||||
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HMBI | HMBI is a fluorescent probe that enables dual-color visualization of both the nucleus and mitochondria and monitors apoptosis. HMBI emits green fluorescence in the nucleus with Ex/Em=405/510-560 nm, and red fluorescence in mitochondria with Ex/Em=543/560-660 nm. The localization and emission properties of HMBI depend on subcellular pH and mitochondrial membrane potential. HMBI can serve as a feed additive for in vitro rumen fermentation; it is partially degraded, absorbed or converted into HMB by microorganisms in the system, so as to support microbial protein synthesis, alter the concentration of rumen metabolites and adjust the composition of bacterial communities. | |||||||||||||||||||||
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FGFR1 inhibitor-15 | FGFR1 inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 of 27 μM. FGFR1 inhibitor-15 can be used in the study of cancer. | |||||||||||||||||||||
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Citrus red 2 | 99.57% | Citrus red 2 (CI Solvent red 80) is a synthetic dye with coloring power and antioxidant activity. Citrus red 2 can be used in food and cosmetics to provide a bright color to the product. Citrus red 2 is also used as a reference substance for testing and analysis in certain situations. | ||||||||||||||||||||
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References
- [1]. Nakamura T et al. Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation. Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. [Content Brief]
- [2]. Chen X, et al. SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1. Redox Biol. 2024 Sep;75:103267. [Content Brief]
